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Development of novel production method of high purity lutetium-177 for advanced cancer therapy

Development of novel production method of high purity lutetium-177 for advanced cancer therapy
开发用于晚期癌症治疗的高纯度镥177的新型生产方法
批准号：
21591586
负责人：
WATANABE Satoshi
金额：
$2.91万
依托单位：
Japan Atomic Energy Agency
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591586/
关键词：
ルテチウム-177分離精製法イミノ二酢酸キレート樹脂Lu-177分離・精製法高純度ルテチム-177

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中文摘要
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英文摘要
Lutetium-177 is considered to have potential for application in radionuclide therapy, because it emits b-particles suitable to penetrate small tumors. In addition, real time imaging of biodistribution can be done by using the ^<177>Lu, because the energy of g-rays emitted from ^<177>Lu is particularly suitable for imaging by single photon emission computed tomography. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added ^<177>Lu produced in the ^<176>Yb(n, g) ^<177>Yb → ^<177>Lu process are desired. In this production, separation of ^<177>Lu from Yb target is required. Therefore, in the present paper, basic study of separation between Lu and Yb by using iminodiacetic acid chelating resin is investigated. It was found that the best separation between Lu and Yb was achieved by using 0.013 M HNO_3 for the eluent and the column of 4.6 mmφｘ450 mm size.
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Production of Lu-177 capable of labeling antibodies.
生产能够标记抗体的 Lu-177。
DOI： --
发表时间： 2009
期刊： JAEA-Review
影响因子： --
作者： [Sa. Watanabe, K. Hashimoto, Sh. Watanabe, Y. Iida, H. Hanaoka, K. Endo and N. S. Ishioka]
通讯作者： K. Endo and N. S. Ishioka
Fundamental Studies for the Development of Systems to Support Health Consultation Activities Focused on Human Communications in Japanese Schools
Theoretical calculations on the effects of local high electric fields at interface atomic/molecular layers
  • 批准号：
    15H03561
  • 项目类别：
    Grant-in-Aid for Scientific Research (B)
  • 资助金额：
    $10.57万
  • 财政年份：
    2015
  • 负责人：
    WATANABE Satoshi
  • 依托单位：
    The University of Tokyo
Social science study for encouraging "environmental reconstruction" following the Great East Japan Earthquake: Construction the sustainable and self-reliant local society model
Fabrication of flexible nano emitting devices consisting of rare-earth-ion-doped phosphor films
  • 批准号：
    24750185
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $3.0万
  • 财政年份：
    2012
  • 负责人：
    WATANABE Satoshi
  • 依托单位：
    Tokyo University of Science
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