Novel hormones and receptors in renal and cardiovascular injuries.

肾脏和心血管损伤中的新型激素和受体。

• 批准号: 21591016
• 负责人: TOTSUNE Kazuhito
• 金额: $ 2.91万
• 依托单位: Tohoku Fukushi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591016/
• 关键词: 遺伝子; 循環器; 高血圧; 腎障害; 脳血管障害; 循環器・高血圧; 生理活性; 発現・制御; プロレニン受容体

Pathophysiological roles of novel hormones and receptors were examined in association with organ injuries. Expressions of adrenomedullin II(AM2) and(pro) renin receptor((P) RR) in the kidney and/or heart were significantly changed in renal failure, cardiac failure and hypertensive animal models. Analyses of gene polymorphisms revealed that the polymorphisms of AM2 and(P) RR were significantly associated with occurrences of cardiac hypertrophy, cerebral lacuna infarction and chronic kidney diseases. These results indicate that these novel hormones and receptors actually play certain roles in the renal and cardiovascular injuries.

新型激素和受体的病理生理作用与器官损伤的关系进行了研究。肾上腺髓质素II（AM2）和（原）肾素受体(P) RR)在肾脏和/或心脏中的表达在肾功能衰竭、心力衰竭和高血压动物模型中发生显著变化。基因多态性分析显示AM2和(P) RR多态性与心脏肥厚、脑腔隙性梗死和慢性肾脏疾病的发生有显著相关性。这些结果表明，这些新的激素和受体在肾脏和心血管损伤中确实起着一定的作用。

项目成果

Expression of prorenin receptor in the human brain and co-localization with arginine vasopression and oxytocin in the hypothalamus

人脑中肾素原受体的表达及其与下丘脑中精氨酸血管加压和催产素的共定位

• 发表时间: 2010
• 作者: Hiraishi K;Hirose T;Yamamoto H;Shoji I;Shibasaki A;Kato I;Kaneko K;Satoh F;Totsune K;Takahashi K.
• 通讯作者: Takahashi K.

Renal expression of(Pro) renin receptor is upregulated in rats with chronic renal failure

慢性肾功能衰竭大鼠肾素受体（Pro）肾表达上调

• 发表时间: 2009
• 作者: Totsune K;Hirose T;Mori N;Metoki H;Asayama K;Kikuya M;Ohkubo T;Takahashi K;Imai Y.
• 通讯作者: Imai Y.

アドレノメデュリン2/インターメジン遺伝子多型と無症候性脳血管障害との関連の検討:大迫研究

肾上腺髓质素2/intermedin基因多态性与无症状脑血管病关系的检验：Osako研究

• 发表时间: 2009
• 作者: 廣瀬卓男;戸恒和人;川村卓也;目時弘仁;星川美奈子;原梓;小原拓;浅山敬;菊谷昌浩;近藤健男;大久保孝義;出江紳一;高橋和広;今井潤
• 通讯作者: 今井潤

Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study

• DOI: 10.1038/ajh.2008.357
• 发表时间: 2009-03-01
• 期刊: AMERICAN JOURNAL OF HYPERTENSION
• 影响因子: 3.2
• 作者: Hirose, Takuo;Hashimoto, Masahiro;Imai, Yutaka
• 通讯作者: Imai, Yutaka

Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study

• DOI: 10.1038/hr.2011.131
• 发表时间: 2011-12-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Hirose, Takuo;Totsune, Kazuhito;Imai, Yutaka
• 通讯作者: Imai, Yutaka