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Novel hormones and receptors in renal and cardiovascular injuries.

Novel hormones and receptors in renal and cardiovascular injuries.
肾脏和心血管损伤中的新型激素和受体。
批准号:
21591016
负责人:
TOTSUNE Kazuhito
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Pathophysiological roles of novel hormones and receptors were examined in association with organ injuries. Expressions of adrenomedullin II(AM2) and(pro) renin receptor((P) RR) in the kidney and/or heart were significantly changed in renal failure, cardiac failure and hypertensive animal models. Analyses of gene polymorphisms revealed that the polymorphisms of AM2 and(P) RR were significantly associated with occurrences of cardiac hypertrophy, cerebral lacuna infarction and chronic kidney diseases. These results indicate that these novel hormones and receptors actually play certain roles in the renal and cardiovascular injuries.
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会议论文
Expression of prorenin receptor in the human brain and co-localization with arginine vasopression and oxytocin in the hypothalamus
人脑中肾素原受体的表达及其与下丘脑中精氨酸血管加压和催产素的共定位
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hiraishi K, Hirose T, Yamamoto H, Shoji I, Shibasaki A, Kato I, Kaneko K, Satoh F, Totsune K, Takahashi K.]
通讯作者: Takahashi K.
Renal expression of(Pro) renin receptor is upregulated in rats with chronic renal failure
慢性肾功能衰竭大鼠肾素受体(Pro)肾表达上调
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Totsune K, Hirose T, Mori N, Metoki H, Asayama K, Kikuya M, Ohkubo T, Takahashi K, Imai Y.]
通讯作者: Imai Y.
アドレノメデュリン2/インターメジン遺伝子多型と無症候性脳血管障害との関連の検討:大迫研究
肾上腺髓质素2/intermedin基因多态性与无症状脑血管病关系的检验:Osako研究
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [廣瀬卓男, 戸恒和人, 川村卓也, 目時弘仁, 星川美奈子, 原梓, 小原拓, 浅山敬, 菊谷昌浩, 近藤健男, 大久保孝義, 出江紳一, 高橋和広, 今井潤]
通讯作者: 今井潤
DOI: 10.1038/ajh.2008.357
发表时间: 2009-03-01
期刊: AMERICAN JOURNAL OF HYPERTENSION
影响因子: 3.2
作者: [Hirose, Takuo, Hashimoto, Masahiro, Imai, Yutaka]
通讯作者: Imai, Yutaka
32
    (Pro)renin receptor in renal and cardiovascular injuries.
    • 批准号:
      25461205
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2013
    • 负责人:
      TOTSUNE Kazuhito
    • 依托单位:
    Molecular mechanism of the novel hormone/receptor systems in renal and cardiovascular dysfunction
    • 批准号:
      19590929
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      TOTSUNE Kazuhito
    • 依托单位:
    Association of gene polymorphisms of hypertension-related vasoactive substances with hypertension and response to the antihypertensive drugs
    • 批准号:
      16590433
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2004
    • 负责人:
      TOTSUNE Kazuhito
    • 依托单位:
    PLASMA LEVELS OF UROTENSIN II AND ITS URINARY EXCRETION IN PATIENTS WITH DIABETES MELLITUS : RELATION WITH DIABETIC NEPHROPATHY
    • 批准号:
      13671094
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2001
    • 负责人:
      TOTSUNE Kazuhito
    • 依托单位:
    海外基金