Research for the progression of encapsulating peritoneal sclerosis

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This study is to assess the efficacy of pyridoxamine against the peritoneal damage under induced by the peritoneal dialysis fluid. We administered pyridoxamine to the peritoneal damage and renal failure model rat. However, we couldn't prove this efficacy of the drug from some reasons, for example, rather minor damage of the peritoneum. We are currently on the re-experiment. Which intends to induce more damage on the peritoneum raising the dose of methylglyoxal, one of the Glucose degradation products. Concurrently, raising the dose of pyridoxamine to make the effect of pyridoxamine more definite. We also examined the pharmacokinetics of the drug with a small number of chronic renal failure patients on peritoneal dialysis. The pyridoxamine concentration in blood and subsequently, concentration of the drug in the peritoneal dialysis fluid effluent raised.