Involvement of RNA-editing enzyme and multi-factor to motor neuron death in patients with sporadic amyotrophic lateral sclerosis

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To examine the effect of multi-factorial involvement, such as RNA-editing enzyme, in the typical neurodegenerative disease, amyotrophic lateral sclerosis (ALS), I established the model for neuronal cell death. For in vitro study, adenovirus system was developed, and for in vivo study the gene-transfer system by electroporation for embryo mice was developed. These systems are very useful for studying multi-factorial system because many genes can be introduced into simultaneously and easily.