Elucidation of the role of microRNA in the intractable neurological disease

本研究旨在阐明microRNA在神经系统难治性疾病中的作用。估计受microRNA调控的疾病相关基因的3‘非编码区被继续进行，以尽可能地确定患者的整个序列。对于多发性硬化症，共选择了IL2RA、IL7R等14个基因。对于肌萎缩侧索硬化症，我们共选择了fus和alsin等16个基因。没有发现患者每个基因的显著突变，但我们假设我计划将结果和数据与其他项目结合起来。

In this study, it is aimed for the elucidation of the role of microRNA in the neurologic intractable disease. The 3' UTR of disease-related genes, which is estimated to be regulated by microRNA, were proceeded to determine the entire sequence in the patient to the extent possible. For multiple sclerosis, a total of 14 genes, such as IL2RA and IL7R was selected. With respect to amyotrophic lateral sclerosis, we selected a total of 16 genes such as FUS and Alsin. The significant mutation by a patient by each gene was not found, but we assumed that I was planning to synthesize the result and data with other projects.