Elucidation of the role of microRNA in the intractable neurological disease

阐明microRNA在难治性神经系统疾病中的作用

• 批准号: 21591087
• 负责人: KAWANO Yuji
• 金额: $ 2.91万
• 依托单位: Kyushu University (2011)Ehime University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591087/
• 关键词: 神経難病; 多発性硬化症; 筋萎縮性側索硬化症; microRNA; 疾患感受性遺伝子; ALS; MS

In this study, it is aimed for the elucidation of the role of microRNA in the neurologic intractable disease. The 3' UTR of disease-related genes, which is estimated to be regulated by microRNA, were proceeded to determine the entire sequence in the patient to the extent possible. For multiple sclerosis, a total of 14 genes, such as IL2RA and IL7R was selected. With respect to amyotrophic lateral sclerosis, we selected a total of 16 genes such as FUS and Alsin. The significant mutation by a patient by each gene was not found, but we assumed that I was planning to synthesize the result and data with other projects.

本研究旨在阐明microRNA在神经系统疑难疾病中的作用。疾病相关基因的3'UTR估计受到microRNA的调节，我们继续尽可能确定患者体内的整个序列。对于多发性硬化症，总共选择了14个基因，例如IL2RA和IL7R。对于肌萎缩侧索硬化症，我们总共选择了FUS、Alsin等16个基因。没有发现患者每个基因的显着突变，但我们假设我打算与其他项目综合结果和数据。

项目成果

Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions

• DOI: 10.1177/1352458509106613
• 发表时间: 2009-09-01
• 期刊: MULTIPLE SCLEROSIS JOURNAL
• 影响因子: 5.8
• 作者: Matsushita, T.;Isobe, N.;Kira, J.
• 通讯作者: Kira, J.

Case of Borrelia brainstem encephalitis presenting with severe dysphagia

伴有严重吞咽困难的疏螺旋体脑干脑炎一例

• 发表时间: 2010
• 期刊: Rinsho Shinkeigaku
• 作者: Kawano Y;Shigeto H;Shiraishi Y;Ohyagi Y;Kira
• 通讯作者: Kira

免疫性神経疾患の高感度自己抗体プロファイル

免疫介导的神经系统疾病的敏感自身抗体谱

• 发表时间: 2010
• 作者: 山本光;田中茂;酒井規雄他;佐々木勉;河野ら
• 通讯作者: 河野ら

Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status

• DOI: 10.1177/1352458509355067
• 发表时间: 2010-02-01
• 期刊: MULTIPLE SCLEROSIS JOURNAL
• 影响因子: 5.8
• 作者: Isobe, N.;Matsushita, T.;Kira, J.
• 通讯作者: Kira, J.

Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians

白细胞介素7受体α基因多态性影响亚洲人多发性硬化症风险

• 发表时间: 2011
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Fang L;Isobe N;Yoshimura S;Yonekawa T;Matsushita T;Masaki K;Doi H;Ochi K;Miyamoto K;Kawano Y;Kira J
• 通讯作者: Kira J