Establishment of immunoassay system for phosphorylated TDP-43 and the study of the localization of phosphorylated TDP-43 using the immunoelectron microscopy

对TDP-43和FUS等DNA/RNA结合蛋白的研究也进行了综述。我在家族性ALS患者中发现了一种新的TARDBP基因突变，并详细发表了他们的临床和病理结果。此外，我发表了关于一例FUS突变的家族性ALS患者、一例伴有大量FUS阳性包涵体的散发性ALS患者以及ALS模型大鼠神经元变性机制的报道。我也在国际会议上读到了关于TDP-43和FUS之间关系的论文。

Several studies about DNA/RNA binding proteins such as TDP-43 and FUS have examined. I found a novel TARDBP gene mutation in familial ALS patients and published the clinical and pathological findings of them in detail. Furthermore, I published the reports about a patient with familial ALS with FUS mutation, a patient with sporadic ALS with numerous FUS-positive inclusions, and the mechanism of neuronal degeneration of the model rats of ALS. I also read the paper about the relationship between TDP-43 and FUS at the international meetings.