The role of tumor suppressor candidate 5 (BEC1/TUSC5) in adipocyte differentiation

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We have previously identified brain endothelial cell derived gene-1 (BEC-1) as a gene dominantly expressed in rat brain endothelial cells using suppression subtractive hybridization technique. Surprisingly, BEC-1 gene was thought to be a rat tumor suppressor candidate 5 (TUSC5), since this gene had considerable homology with both mouse TUSC5 and human located at seventeen-p-thirteen point three 1 (LOST1) categorized as human TUSC5. The expression of TUSC5 and adiponectin mRNA was induced drastically during the differentiation followed by PPARγ-accumulation. Furthermore pioglitazone, a PPARγ ligand, facilitated dose-dependent induction of TUSC5 as well as differentiation in both human preadipocytes and mouse 3T3-L1 cells. Thus, TUSC5 is a PPARγ inducible gene and may play a role for the regulation of adipocyte function.