Establishment of optimal hematopoietic stem cell transplantation donor selection based on analysis of immune-related gene polymorphism
Establishment of optimal hematopoietic stem cell transplantation donor selection based on analysis of immune-related gene polymorphism
批准号:
21591236
负责人:
TAKAMI Akiyoshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
When the impact of immune-related gene polymorphisms was examined in patients and their donors of unrelated hematopoietic stem cell transplantation, genetic variations in the NKG2D, Granzyme B, CXCL10, NLRP3, FCGR3A, IL-17, and PTPN22 genes were associated with transplant outcomes. Experimental investigation revealed that the gene polymorphisms of NKG2D, IL-17 and CXCL10 play functionally important roles in the regulation of their production. These findings suggest that determination of such gene polymorphisms prior to transplantation offer clinical benefits in patients undergoing allogeneic hematopoietic stem cell transplantation
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生着不全に対する再移植:One day regimenの試み
植入失败再次移植:一日方案试验
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takahashi S, Ooi J, Kato S, Kawakita T, Nakauchi Y, Monna M, Nagamura T, Kato K, Yamaguchi T., Asano S, 山崎雅英, 高見昭良]
通讯作者:
高見昭良
Aminor genetic variation in the Granzyme B gene predicts relapse after HLA-funy-matched unrelated bone marrow transplantation for hemato logic malignancies
颗粒酶 B 基因的微小遗传变异可预测 HLA 匹配的无关骨髓移植治疗血液系统恶性肿瘤后的复发
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Espinoza JL, Takami A]
通讯作者:
Takami A
Significant Impact of IL-17A Gene Polymorphism On Transplant Outcomes After HLA-Fully-Matched Unrelated Bone Marrow Transplantation
IL-17A基因多态性对HLA全匹配非亲缘骨髓移植后移植结果的显着影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[山崎雅英, 森下英理子, 朝倉英策, 中尾眞二, Takami A]
通讯作者:
Takami A
DOI:
10.1111/j.1399-3062.2011.00670.x
发表时间:
2012-04-01
期刊:
TRANSPLANT INFECTIOUS DISEASE
影响因子:
2.6
作者:
[Hosokawa, K., Yamazaki, H., Nakao, S.]
通讯作者:
Nakao, S.
Intensive chemotherapy for a relapsed ALL patient who received living-donor lobar lung transplantation.Bone Marrow Transplant
接受活体肺叶移植的复发性 ALL 患者的强化化疗。骨髓移植
DOI:
--
发表时间:
2011
期刊:
Bone Marrow Transplant
影响因子:
--
作者:
[Ishiyama K, Takami A]
通讯作者:
Takami A
共 32 条
Establishment of tailor-made type allogeneic hematopoietic stem cell transplantation based on immune-modulating gene polymorphism analysis
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批准号:24591418
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:TAKAMI Akiyoshi
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依托单位:
Induction of cytotoxic T lymphocytes specific for minor histocompatility antigen through transferringThell receptor gene
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批准号:18591049
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:TAKAMI Akiyoshi
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依托单位:
海外基金