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The role of CD95-induced apoptosis system in the maturation and differentiation stages of self-antigen specific B cells

The role of CD95-induced apoptosis system in the maturation and differentiation stages of self-antigen specific B cells
CD95诱导的凋亡系统在自身抗原特异性B细胞成熟和分化阶段的作用
批准号:
21591352
负责人:
KASAHARA Yoshihito
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To examine the functional roles of CD95-induced apoptosis in B cell differentiation and maturation stages, B cell antigen expression and repertoire were analyzed. Increase of CD19-positive, CD20-negative cells including CD38 positive, IgD negative, CD95positive memory B cells, plasmablast and plasma cells were found in circulation in patients with infection and autoimmune disease. These results indicated that anomaly of CD95-induced apoptosis systems in B cell maturation may relate to the pathogenesis of autoimmune disease.
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Monitoring of Epstein-Barr virusinfectedcells by flow cytometer permits early diagnosis and evaluation of disease progression in EBV-associated hemophagocyticlymphohistiocytosis
通过流式细胞仪监测 Epstein-Barr 病毒感染的细胞可以早期诊断和评估 EBV 相关噬血细胞性淋巴组织细胞增多症的疾病进展
DOI: --
发表时间: 2012
期刊: Rinsho Ketsueki
影响因子: --
作者: [Fukuda M, Nishimura R, Araki R, KurodaR, Mase S, Nakagawa Y, Tone Y, Maeba H, Wada T, Kasahara Y, Yachie A]
通讯作者: Yachie A
Distinct cytokine profile of systemic juvenile-idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis
系统性幼年特发性关节炎相关巨噬细胞活化综合征的独特细胞因子谱,特别强调白介素 18 在其发病机制中的作用
DOI: --
发表时间: 2010
期刊: Rheumatology
影响因子: 5.5
作者: [Shimizu, M, Kasahara Y, et al]
通讯作者: et al
Analysisof cytokine, chemokine production bynewly established EBV-positive NK or Tcell lines
新建立的 EBV 阳性 NK 或 T 细胞系的细胞因子、趋化因子产生分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kasahara Y, Nishida M]
通讯作者: Nishida M
Hyper IgD andperiodic fever syndrome in Japan
日本的高 IgD 和周期性发热综合征
DOI: --
发表时间: 2010
期刊: J. Tokyo Med Univ
影响因子: --
作者: [河島尚志, 金兼弘和, 森雅亮, 今中啓之, 新庄正宜, 村田卓士, 笠原善仁, 谷口義弘, 杉田完爾, 宮脇利男]
通讯作者: 宮脇利男
23
    Role of CD95-induced apoptotic system in double negative regulatory T cells
    • 批准号:
      19591243
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      KASAHARA Yoshihito
    • 依托单位:
    Significance of CD244 expression in functional development of CD8+ cytotoxic T lymphocytes
    • 批准号:
      16591013
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.37万
    • 财政年份:
      2004
    • 负责人:
      KASAHARA Yoshihito
    • 依托单位:
    Biological analysis of Fas- or Fas ligand gene mutations and basic analysis of gene therapy
    • 批准号:
      10670710
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      1998
    • 负责人:
      KASAHARA Yoshihito
    • 依托单位:
    Significance of Reactive Oxygen Intermediates in Fas-mediated apoptosis.
    • 批准号:
      08670862
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.47万
    • 财政年份:
      1996
    • 负责人:
      KASAHARA Yoshihito
    • 依托单位:
    海外基金