possible inhibitory action of omega-3 unsatulated fatty acid on development of childhood asthma

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Childhood asthma has been known to be a chronic airway inflammation which is characterized by infiltration of inflammatory cells including lymphocytes, mast cells, eosinophils and PMNs. We investigated action of various bioactive substances including unsaturated fatty acid-metabolites and cytokines in human and murine cultured airway epithelial cells.(1) Leukotrienes(LTB4), a substance of unsaturated fatty acid induced ICAM-1 expression on cultured human airway epithelial cells, indicating important roles in the process of virus-induced inflammation of airway.(2) Poly IC induced sema3A in cultured human airway epithelial cells. Sema3A increased phagocytotic function of human PMNs.(3) IL-13 was confirmed to stimulate proliferation of cultured murine tracheal epithelial cells by using air-liquid interface assay. This proliferative action is associated with new induction of epigen, which is a substance of epidermal growth factor receptor(EGFR) ligand family.