Research on the pathogenesis and treatment of Epstein-Barr virusassociated intractable diseases

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In patients with chronic active Epstein-Barr virus infection(CAEBV) or EBVassociated hemophagocytic syndrome(EBV-HLH), EBVpositive T/NK cells were suggested to arise from hematopoietic progenitors and need CD4positive cells for the clonal proliferation in a distinct manner from tumorigenesis. Early immunomodulatory therapy effectively controlled EBV-HLH in children with primary infection. Long-term outcomes of pediatric patients were favorable after hematopoietic stem cell transplantation, while adult patients had poor outcomes. Characterization of EBVinfected T/NK cells is critical for the establishment of treatment strategy.