The relationship of cutaneous carcinogenesis and polymorphisms in the pigment-regulating genes including MC1R and P

日本老龄化社会带来了更多的恶性皮肤肿瘤患者。太阳暴晒是诱发皮肤癌前病变和恶性肿瘤的最基本的环境因素。最近对遗传性色素异常的研究发现了控制肤色的基因。我们目前正在研究皮肤癌变与色素调节基因MC1R和P的多态之间的关系。这项研究将确定推荐更强烈地保护日光照射的日本人亚群。

The aging society in Japan brings increased affected number of individuals with malignant cutaneous tumors. Sun exposure is the most essential environmental factor inducing cutaneous precancerosis and malignant tumors. Recent studies for inherited pigment anomalies identified the genes regulating skin color. We are currently investigating the relationship of cutaneous carcinogenesis and polymorphisms in the pigment-regulating genes including MC1R and P. This study would identify the Japanese subgroup to be recommended to protect sun exposure more intensively.