Roll of skin antioxidant system in UV irradiation and epidermal morphogenesis/differentiation
Roll of skin antioxidant system in UV irradiation and epidermal morphogenesis/differentiation
批准号:
21591454
负责人:
KAWACHI Yasuhiro
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of premature skin aging, termed photoaging. The harmful effects of UV in photoaging are associated with the generation of reactive oxygen species, and cellular antioxidants act to prevent the occurrence and reduce the severity of UV-induced photoaging. The transcription factor Nrf2 and its cytoplasmic anchor protein, Keap1, are central regulators of the cellular antioxidant response. Here, we investigated the role of the Nrf2. Keap1 pathway in photoaging using nrf2 gene-deficient (nrf2-/-) mice. Our results indicated that UVB-irradiated nrf2-/-mice showed accelerated photoaging, such as coarse wrinkle formation, loss of skin flexibility, epidermal thickening, and deposition of extracellular matrix in the upper dermis. In addition, nrf2-/-mice also showed an increase in cutaneous reactivity for the lipid peroxidation product 4-hydroxy-2-nonenal and a significant decrease in cutaneous glutathione level. These findings indicate that Nrf2 plays the important role in the protection against UVB-induced photoaging.
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DOI:
10.1016/j.bbrc.2009.06.136
发表时间:
2009-09-11
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Kimura, Shintarou, Warabi, Eiji, Ishii, Tetsuro]
通讯作者:
Ishii, Tetsuro
DOI:
10.1038/jid.2010.229
发表时间:
2011-01-01
期刊:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
影响因子:
6.5
作者:
[Taguchi, Shijima, Kawachi, Yasuhiro, Otsuka, Fujio]
通讯作者:
Otsuka, Fujio
DOI:
10.1111/j.1600-0625.2008.00802.x
发表时间:
2009-04
期刊:
Experimental Dermatology
影响因子:
3.6
作者:
[Y. Fujisawa;T. Nabekura;Tomohei Nakao;Yasuhiro Nakamura;Takenori Takahashi;Y. Kawachi;F. Otsuka;M. Onodera]
通讯作者:
Y. Fujisawa;T. Nabekura;Tomohei Nakao;Yasuhiro Nakamura;Takenori Takahashi;Y. Kawachi;F. Otsuka;M. Onodera
Perforated ischiogluteal bursitis mimicking a gluteal decubitus ulcer in patients with spinal cord injury : report of 2 cases.
脊髓损伤患者出现类似臀肌褥疮溃疡的坐骨臀肌滑囊炎穿孔:2 例报告。
DOI:
--
发表时间:
2010
期刊:
Arch Dermatol. 146(8)
影响因子:
--
作者:
[Fujisawa Y, Ito M, Nakamura Y, Furuta J, Ishii Y, Kawachi Y, Otsuka F]
通讯作者:
Otsuka F
Chronically recurrent and disseminated tinea faciei/corporis--autoinoculation from asymptomatic tinea capitis carriage.
慢性复发性和播散性面癣/体癣——无症状头癣携带者的自身接种。
DOI:
--
发表时间:
2010
期刊:
Pediatr Dermatol. 27(5)
影响因子:
--
作者:
[Kawachi Y, Ikegami M, Takase T, Otsuka F]
通讯作者:
Otsuka F
共 17 条
Role of Nrf2 in photoaging and epidermal keratinization
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批准号:24591642
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
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负责人:KAWACHI Yasuhiro
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依托单位:
The role of the novel calcium-responsive transcription factors in kerationocyte proliferation and differentiation
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批准号:19591296
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资助金额:$2.83万
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财政年份:2007
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负责人:KAWACHI Yasuhiro
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依托单位:
Attenuation of UVB-induced sun burn reaction, DNA damage and epidermal cell apoptosis but no alteration in UVB-induced skin carcinogenesis in Nrf2 deficient mice
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项目类别:Grant-in-Aid for Scientific Research (C)
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负责人:KAWACHI Yasuhiro
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依托单位:
Role of Nrf2 in differentiation and UV reaction of Keratinocytes and melanocytes
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批准号:15591167
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:2003
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负责人:KAWACHI Yasuhiro
-
依托单位:
Anakysis of GATA-3 function in proliferation and differentiation of kerationocytes
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批准号:13670865
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
-
财政年份:2001
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负责人:KAWACHI Yasuhiro
-
依托单位:
国内基金
海外基金
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