Analysis of novel homeostatic regulator of the skin.
Analysis of novel homeostatic regulator of the skin.
批准号:
21591464
负责人:
KATAYAMA Ichiro
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
The role of 11βHSD1 in skin homeostasis was studied. The mRNA expression and protein level of 11βHSD1 increased by stimuli, such as UVB, haptens, and TNFα. 11βHSD1 knockdown by si11βHSD1 and 11βHSD1 inhibition by specific inhibitor suppressed differentiation of keratinocytes and enhanced proliferation. In vivo studies, selective inhibitor of 11βHSD1 promoted cutaneous wound healing. Taken together, we consider that 11βHSD1 acting as a regulator of keratinocytes proliferation and differentiation.
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DOI:
10.1038/ni.1885
发表时间:
2010-07
期刊:
Nature immunology
影响因子:
30.5
作者:
[]
通讯作者:
11β-HSD as a novel regulator of epidermal differentiation : Considering the possible involvement in aberrant keratinizating disorders
11β-HSD 作为表皮分化的新型调节剂:考虑到可能参与异常角化性疾病
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Mika Terao, Hiroyuki Murota, Akihiro Kimura, Arisa Kato, Ken Igawa, Ichiro Katayama, Mika Terao]
通讯作者:
Mika Terao
DOI:
10.1111/j.1346-8138.2009.00706.x
发表时间:
2009-10-01
期刊:
JOURNAL OF DERMATOLOGY
影响因子:
3.1
作者:
[Saeki, Hidehisa, Furue, Masutaka, Takehara, Kazuhiko]
通讯作者:
Takehara, Kazuhiko
DOI:
10.4049/jimmunol.1003485
发表时间:
2011-03-01
期刊:
JOURNAL OF IMMUNOLOGY
影响因子:
4.4
作者:
[Nakagawa, Yukinobu, Takamatsu, Hyota, Kumanogoh, Atsushi]
通讯作者:
Kumanogoh, Atsushi
アトピー性皮膚炎患者における前向きアンケート調査の開始時基礎情報 (第1報)
特应性皮炎患者前瞻性问卷调查开始时的基本信息(第一份报告)
DOI:
--
发表时间:
2009
期刊:
臨床皮膚科 63(6)
影响因子:
--
作者:
[古江増隆, 他13名(11番目)]
通讯作者:
他13名(11番目)
共 30 条
Analysis of the immune response to ectopically expressed allergen gene into epidermis
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批准号:18591246
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
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财政年份:2006
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负责人:KATAYAMA Ichiro
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BIOLOGICAL CLOCK AND CYTOKINE NETWORK
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批准号:15591183
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资助金额:$2.18万
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负责人:KATAYAMA Ichiro
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Regulatory mechanisms of neuro-endocine-immune system in the skin
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批准号:12470178
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.2万
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财政年份:2000
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负责人:KATAYAMA Ichiro
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依托单位:
Development of a new ion-guide with use of magnetic field
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批准号:10440069
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.33万
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财政年份:1998
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负责人:KATAYAMA Ichiro
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依托单位:
IDENTIFICATION AND REGULATORY MECHANISMS OF INTRINSIC ANTI-INFLAMMATORY MOLECULES IN THE SKIN
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批准号:09670885
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1997
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负责人:KATAYAMA Ichiro
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依托单位:
High precision measurements for unstable nuclei using an ion trap
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批准号:05044043
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.2万
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财政年份:1993
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负责人:KATAYAMA Ichiro
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依托单位:
Laser cooling of unstable nuclear ions in an ion trap
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批准号:04452022
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$5.44万
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财政年份:1992
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负责人:KATAYAMA Ichiro
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依托单位:
Analysis of mechanism of desensitization of contact dermatitis
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批准号:03670521
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1991
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负责人:KATAYAMA Ichiro
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依托单位: