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Analysis of novel homeostatic regulator of the skin.

Analysis of novel homeostatic regulator of the skin.
新型皮肤稳态调节剂的分析。
批准号:
21591464
负责人:
KATAYAMA Ichiro
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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项目成果

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中文摘要
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英文摘要
The role of 11βHSD1 in skin homeostasis was studied. The mRNA expression and protein level of 11βHSD1 increased by stimuli, such as UVB, haptens, and TNFα. 11βHSD1 knockdown by si11βHSD1 and 11βHSD1 inhibition by specific inhibitor suppressed differentiation of keratinocytes and enhanced proliferation. In vivo studies, selective inhibitor of 11βHSD1 promoted cutaneous wound healing. Taken together, we consider that 11βHSD1 acting as a regulator of keratinocytes proliferation and differentiation.
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DOI: 10.1038/ni.1885
发表时间: 2010-07
期刊: Nature immunology
影响因子: 30.5
作者: []
通讯作者:
11β-HSD as a novel regulator of epidermal differentiation : Considering the possible involvement in aberrant keratinizating disorders
11β-HSD 作为表皮分化的新型调节剂:考虑到可能参与异常角化性疾病
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Mika Terao, Hiroyuki Murota, Akihiro Kimura, Arisa Kato, Ken Igawa, Ichiro Katayama, Mika Terao]
通讯作者: Mika Terao
DOI: 10.1111/j.1346-8138.2009.00706.x
发表时间: 2009-10-01
期刊: JOURNAL OF DERMATOLOGY
影响因子: 3.1
作者: [Saeki, Hidehisa, Furue, Masutaka, Takehara, Kazuhiko]
通讯作者: Takehara, Kazuhiko
DOI: 10.4049/jimmunol.1003485
发表时间: 2011-03-01
期刊: JOURNAL OF IMMUNOLOGY
影响因子: 4.4
作者: [Nakagawa, Yukinobu, Takamatsu, Hyota, Kumanogoh, Atsushi]
通讯作者: Kumanogoh, Atsushi
30
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    • 批准号:
      18591246
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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      2000
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    • 项目类别:
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      1998
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