The effects of immature cells in the hypothalamus on food intake and weight gain

下丘脑未成熟细胞对食物摄入和体重增加的影响

• 批准号: 21591490
• 负责人: INOUE Yuichirou
• 金额: $ 2.66万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591490/
• 关键词: オランザピン; 体重増加; ガラニン; 脂肪細胞; Olig2

Weight gain is increasingly recognized as an unwanted side effect of atypical antipsychotic drugs. To explore the mechanisms underlying this side effect, we examined the effects of olanzapine, an atypical antipsychotic drug, on cellular proliferation and differentiation in the adult mouse hypothalamus.We found that the treatment increased BrdU-incorporating cell numbers in the hypothalamus, while the same regimen with haloperidol or control had little effect on cellular proliferation. Double-labeling immunohistochemistry revealed that the majority of the BrdU-positive cells were also Olig2-or APC-positive, indicating that oligodendrocyte-lineage cells were generated in response to olanzapine treatment.These findings suggest a possible link between gliogenesis in the hypothalamus and weight gain following olanzapine treatment

体重增加越来越被认为是非典型抗精神病药物的不良副作用。为了探讨这种副作用的机制，我们研究了非典型抗精神病药物奥氮平对成年小鼠下丘脑细胞增殖和分化的影响。我们发现，治疗增加了下丘脑中掺入BrdU的细胞数量，而相同方案的氟哌啶醇或对照组对细胞增殖几乎没有影响。免疫组织化学双标记法显示，大多数BrdU阳性细胞也呈Orig2或APC阳性，这表明奥氮平治疗后产生了少突胶质细胞系细胞。这些发现提示下丘脑胶质细胞的形成与奥氮平治疗后体重增加之间可能存在联系

项目成果

Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus

• DOI: 10.1016/j.neuint.2010.07.003
• 发表时间: 2010-11
• 期刊: Neurochemistry International
• 影响因子: 4.2
• 作者: Takahira Yamauchi;K. Tatsumi;M. Makinodan;S. Kimoto;M. Toritsuka;H. Okuda;T. Kishimoto;A. Wanaka

Olanzapine treatment induces Olig2-positive cell proliferation in the hypothalamus with weight gain and enlarged fat tissues

奥氮平治疗诱导下丘脑 Olig2 阳性细胞增殖，导致体重增加和脂肪组织增大

• 发表时间: 2010
• 作者: Tanii H;Nishimura Y;et al;山内崇平
• 通讯作者: 山内崇平