Studies about gimeracil, a radiosensitizer

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We studied the radiosensitizing effects of gimeracil, a component of TS-1, an anti-cancer drug. We obtained the following results. Gimeracil had the radiosensitizing effects in all different 10 cells examined. Gimeracil did not influence the cell cycle. Gimeracil partially inhibited the homologous recombination repair(HR) of DNA double strand breaks. dihydropyrimidine dehydrogenase(DPYD) is the target protein for radiosensitization by Gimeracil. The inhibitors of DPYD such as Gimeracil could enhance the efficacy of radiotherapy through partial suppression of HR-mediated DNA repair.