Development of small-diameter vascular graft composed of antithrombogenic phospholipid polymer

抗血栓磷脂聚合物小直径血管移植物的研制

• 批准号: 21591628
• 负责人: OKAMOTO Hiroyuki
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591628/
• 关键词: 小口径人工血管; MPCポリマー; 抗血栓性

The patency rates of carotid or femoral arterial bypass with MPC-coated and noncoated ePTFE grafts were 9/37(24%) and 14/37(38%) after one week ; 4/37(11%) and 6/37(15%) after two weeks ; and 3/37(8%) and 3/37(8%) after four weeks. Based on a histological examination, the thrombus was attached to the cut edges of the host artery. Intimal hyperplasia at the anastomosis and the surface of MPC-coated grafts was not changed remarkably compared with noncoated grafts.

使用MPC涂层和无涂层ePTFE移植物的颈动脉或股动脉旁路术的通畅率在1周后分别为9/37（24%）和14/37（38%）; 2周后分别为4/37（11%）和6/37（15%）; 4周后分别为3/37（8%）和3/37（8%）。根据组织学检查，血栓附着在宿主动脉的切割边缘。与未涂层移植物相比，MPC涂层移植物的吻合口和表面的内膜增生没有显着变化。