Molecular mechanism of solid tumor growth inhibition by a new differentiation inducer and rapamycin

我们研究了一种新的白血病细胞分化诱导剂是否能抑制实体瘤细胞的增殖。我们最近在体外和体内实验中发现，子叶列宁A和雷帕霉素协同抑制人乳腺癌细胞的生长。在本研究中，我们发现，至少在一定程度上，cotylenin阻断了雷帕霉素诱导的Akt信号的反馈激活，导致了cotylenin A和雷帕霉素对乳腺癌细胞的协同生长抑制。

We have examined whether a new differentiation inducer of leukemic cells can suppress the proliferation of solid tumor cells. We recently found that cotylenin A and rapamycin synergistically inhibited the growth of human mammary cancer cells in vitro and in vivo. In this study we found that the abrogation by cotylenin of the rapamycin-induced feedback activation of Akt signaling contributed, at least in part, to the synergistic growth inhibition of mammary cancer cells induced by treatment with cotylenin A and rapamycin.