Molecular mechanism of solid tumor growth inhibition by a new differentiation inducer and rapamycin

新型分化诱导剂和雷帕霉素抑制实体瘤生长的分子机制

• 批准号: 21591686
• 负责人: KASUKABE Takashi
• 金额: $ 2.91万
• 依托单位: Research Institute for Clinical Oncology, Saitama Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591686/
• 关键词: Cotylenin A; Rapamycin; 分化誘導剤; 乳癌細胞; 増殖抑制; 併用効果; Aktリン酸化; mTOR; 三酸化ヒ素; アポトーシス; 卵巣癌細胞; セルシグナリング; Akt

We have examined whether a new differentiation inducer of leukemic cells can suppress the proliferation of solid tumor cells. We recently found that cotylenin A and rapamycin synergistically inhibited the growth of human mammary cancer cells in vitro and in vivo. In this study we found that the abrogation by cotylenin of the rapamycin-induced feedback activation of Akt signaling contributed, at least in part, to the synergistic growth inhibition of mammary cancer cells induced by treatment with cotylenin A and rapamycin.

我们研究了一种新的白血病细胞分化诱导剂是否能抑制实体瘤细胞的增殖。我们最近发现，cotylenin A和雷帕霉素在体外和体内协同抑制人乳腺癌细胞的生长。在这项研究中，我们发现棉花素消除了雷帕霉素诱导的Akt信号反馈激活，至少部分地导致了棉花素A和雷帕霉素治疗诱导的乳腺癌细胞的协同生长抑制。

项目成果

Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells

• DOI: 10.1007/s12185-010-0627-4
• 发表时间: 2010-07-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Hagiwara, Yuki;Kasukabe, Takashi;Okabe-Kado, Junko
• 通讯作者: Okabe-Kado, Junko

Extracellular NM23 protein as a therapeutic target for hematological malignancy

细胞外 NM23 蛋白作为血液恶性肿瘤的治疗靶点

• 发表时间: 2012
• 期刊: Adv. Hematol
• 作者: Okabe-Kado;J.;Kasukabe;T.;Kaneko;Y.
• 通讯作者: Y.

Extracellular NM23-H1 protein inhibits the survival of primary cultured normal human peripheral blood mononuclear cells and activates the cytokine production

胞外NM23-H1蛋白抑制原代培养的正常人外周血单核细胞的存活并激活细胞因子的产生

• 发表时间: 2009
• 期刊: Int.J.Hematol. 90
• 作者: Okabe-Kado J.;Kasukabe T
• 通讯作者: Kasukabe T

PI-103 and cotylenin A synergistically inhibit growth of rapamycin-sensitive and-resistant mammary cancer cells

PI-103 和 cotylenin A 协同抑制雷帕霉素敏感和耐药乳腺癌细胞的生长

• 发表时间: 2010
• 作者: 粕壁隆;他2名
• 通讯作者: 他2名

Extracellular NM23 protein promotes the growth and survival of primary cutured human acute myelogenous leukemia cells

胞外NM23蛋白促进原代培养人急性髓系白血病细胞的生长和存活

• 发表时间: 2009
• 期刊: Cancer Sci
• 影响因子: 5.7
• 作者: Okabe-Kado;J.;Kasukabe;T.;Honma;Y.;Kobayashi;H.;Kaneko;Y.
• 通讯作者: Y.