New combinatorial approach to peritoneal dissemination of scirrhous gastric carcinoma based REIC/Dkk-3 gene therapy

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A single intraperitoneal injection of REIC/Dkk-3 adenovirus suppressed tumor dissemination and disease progression of scirrhous gastric carcinoma(SGC) in the mouse model. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that REIC/Dkk-3 gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC. We also demonstrated that PINK1, a key molecule for the mitochondrial protection system, was a new target molecule to sensitize resistant cancer cells to REIC/Dkk-3 gene therapy.