Analysis of heterogeneity related g factors in carcinogenesis of lung cancer.

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Lung cancer has been the most common cancer in the world for several decades and the prognosis is currently unacceptable. Activating mutations in the epidermal growth factor receptor(EGFR) gene in lung adenocarcinoma are associated with a dramatic clinical response to EGFR-tyrosine kinase inhibitors(TKI). However, patients often experience a relapse. However, the whole picture and biological significance regarding acquired resistance remains unclear. in this research. We planned the experiment to establish the visualization for the cancer cell transferred for GFR gene transiently and stably by using lung cancer cell lines, measurement for tumor growth potential by co-culture, and investigation of relationship between mix ratio and drug resistance to EGFR-TKI. We also examined the clinical feature of adenosquamous cell carcinoma as a representative model for heterogeneity of the tumor. Furtherer, our results showed that various alterations in gene or protein expression can account for all resistant mechanisms and this phenomenon suggests the existence of complicated relationships among acquired resistance-related genes. We also reported that T790M may thus be a useful marker for predicting a favorable prognosis in Japanese patients treated by an EGFR-TKI.