Patho-mechanism of discogenic low back pain

背景资料概要：BDNF--背根神经节神经元中的神经营养因子--被顺行运输到脊髓并传递疼痛信号。尽管其与椎间盘源性疼痛的关系尚不清楚，但最近有报道称其存在于退行性IVD的外周部位。直接椎间盘内应用的抗BDNF抗体显着抑制CGRP的生产和BDNF的局部浓度。我们的研究结果表明BDNF的局部产生和椎间盘源性疼痛的病理生理学之间可能存在联系。

SUMMARY OF BACKGROUND DATA : BDNF-a neurotrophin in DRG neurons-is anterogradely transported to the spinal cord and transmits pain signals. Its presence in the peripheral sites of degenerative IVDs has been recently reported, although its association with discogenic pain remains unclear. Direct intradiscal application of the anti-BDNF antibody significantly suppressed both CGRP production and the local concentration of BDNF. Our results indicate a possible association between the local production of BDNF and the pathophysiology of discogenic pain.