Involvement of VIP Signaling in Right Cardiac Hypertrophy

VIP 信号参与右心肥厚

• 批准号: 21591981
• 负责人: WATANABE Itaru
• 金额: $ 2.91万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591981/
• 关键词: 右心肥大; PACAP/VIP; 心臓神経叢; 遺伝子治療; レンチウイルス; 心肥大; VIP; PACAP; プラスミドベクター

Elevated PACAP but not VIP signaling was associated with right ventricular hypertrophy and heart failure induced with monocrotaline in rats. PACAP-preferring receptor PCAl and the common receptor VPAC2 were up-regulated in both ventricles. Thus, PACAP signaling may play a more predominant role during cardiac hypertrophy and hear failure.

野百合碱诱导的大鼠右室肥厚和心力衰竭与PACAP升高有关，而与VIP信号无关。PACAP受体PCA1和共同受体VPAC2在双侧脑室表达上调。因此，PACAP信号可能在心肌肥厚和心力衰竭过程中发挥更重要的作用。

项目成果

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Involvement of PACAP Signaling in Right Cardiac Hypertrophy Induced With Monocrotaline in Rats

PACAP 信号参与野百合碱诱导的大鼠右心肥大

• 发表时间: 2012
• 作者: Motokazu Koga;Yusuke Mizuno;Hiromasa Kawakami;Itaru Watanabe;Takahisa Goto
• 通讯作者: Takahisa Goto

Altered expression in pituitary adenylate cyclase-activatin polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats

野百合碱诱导的大鼠肺动脉高压中垂体腺苷酸环化酶激活素多肽及其受体表达的改变

• 发表时间: 2011
• 作者: Motokazu Koga;Yusuke Mizuno;Hiromasa Kawakami;Itaru Watanabe;Takahisa Goto;Yusuke Mizuno
• 通讯作者: Yusuke Mizuno

Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats

野百合碱诱导大鼠肥厚性右心室中 VIP/VPAC2 表达的改变

• 发表时间: 2009

Altered expression in pituitary adenylate cyclase-activating polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats

野百合碱诱导的大鼠肺动脉高压中垂体腺苷酸环化酶激活多肽及其受体表达的改变

• 发表时间: 2011
• 作者: Yusuke Mizuno;Motokazu Koga;Tomoya;Irie;Kakahisa Goto
• 通讯作者: Kakahisa Goto