Involvement of VIP Signaling in Right Cardiac Hypertrophy
Involvement of VIP Signaling in Right Cardiac Hypertrophy
批准号:
21591981
负责人:
WATANABE Itaru
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
在野百合碱诱导的大鼠中,PACAP信号升高而非VIP信号与右心室肥厚和心力衰竭相关。PACAP偏好受体PCA1和共同受体VPAC 2在两个心室中上调。因此,PACAP信号可能在心肌肥厚和心力衰竭中发挥更重要的作用。
英文摘要
Elevated PACAP but not VIP signaling was associated with right ventricular hypertrophy and heart failure induced with monocrotaline in rats. PACAP-preferring receptor PCAl and the common receptor VPAC2 were up-regulated in both ventricles. Thus, PACAP signaling may play a more predominant role during cardiac hypertrophy and hear failure.
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DOI:
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发表时间:
期刊:
影响因子:
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作者:
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通讯作者:
Involvement of PACAP Signaling in Right Cardiac Hypertrophy Induced With Monocrotaline in Rats
PACAP 信号参与野百合碱诱导的大鼠右心肥大
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Motokazu Koga, Yusuke Mizuno, Hiromasa Kawakami, Itaru Watanabe, Takahisa Goto]
通讯作者:
Takahisa Goto
Altered expression in pituitary adenylate cyclase-activatin polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats
野百合碱诱导的大鼠肺动脉高压中垂体腺苷酸环化酶激活素多肽及其受体表达的改变
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Motokazu Koga, Yusuke Mizuno, Hiromasa Kawakami, Itaru Watanabe, Takahisa Goto, Yusuke Mizuno]
通讯作者:
Yusuke Mizuno
Altered expression in pituitary adenylate cyclase-activating polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats
野百合碱诱导的大鼠肺动脉高压中垂体腺苷酸环化酶激活多肽及其受体表达的改变
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yusuke Mizuno, Motokazu Koga, Tomoya, Irie, Kakahisa Goto]
通讯作者:
Kakahisa Goto
Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats
野百合碱诱导大鼠肥厚性右心室中 VIP/VPAC2 表达的改变
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[]
通讯作者:
Exosome of mesenchymal stem cells for the treatment of pulmonary hypertension with microRNA.
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批准号:17K11059
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2017
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负责人:WATANABE Itaru
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依托单位:
Usege of lentiviral vector for treatment of pulmonary hypertension
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批准号:24592309
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:WATANABE Itaru
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依托单位:
海外基金