Functional analysis of prostate cancer spheroid forming related genes and its clinical application
Functional analysis of prostate cancer spheroid forming related genes and its clinical application
批准号:
21592034
负责人:
WATANABE Masatoshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
提取了包括Plk 2在内的与球状体形成相关的候选基因。我们通过RNAi技术抑制plk 2的表达,分析plk 2对DU-145球状体特征和抗癌药物抗性的影响。结果提示Plk 2可能参与了肿瘤生长的抑制和抗癌药物耐药性的获得。
英文摘要
Some genes including the Plk2were extracted as a candidate gene related with spheroid formation. We analyzed effects of the Plk2on the spheroid characterization and anticancer drug resistance in DU-145 spheroids by suppressing plk2with RNAi. The results indicate that the Plk2may be involved in suppression of tumor growth and acquisition of anticancer drug resistance.
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Editorial Comment on Article (Maspin expression in renal cell carcinoma and its correlation with clinicopathologic parameters).(Invited)
文章评论(肾细胞癌中Maspin的表达及其与临床病理参数的相关性)。(特邀)
DOI:
--
发表时间:
2010
期刊:
Urology
影响因子:
2.1
作者:
[Skamoto S, Naya Y, Shigeta Y, et al, M.Watanabe.]
通讯作者:
M.Watanabe.
前立腺がんスフェロイドの抗癌剤抵抗性へのplk2遺伝子の関与について
plk2基因参与前列腺癌球体抗癌耐药性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[菅原健太郎, 讃良茂浩, 米田操, 広川佳史, 白石泰三, 高木陽光, 渡邉昌俊]
通讯作者:
渡邉昌俊
長期経過中に多彩な合併症を呈したMcCune-Albright syndromeの1例
长期出现各种并发症的麦库尼-奥尔布赖特综合征一例
DOI:
--
发表时间:
2010
期刊:
ホルモンと臨床
影响因子:
--
作者:
[荒木里香, 三崎盛治, 町野由佳, 中山茂穂, 渡辺昌俊, 渡辺典子, 成瀬光栄]
通讯作者:
成瀬光栄
The chromosomal constitution of postmitotic neurons, assessed by neuronal nuclear transfer into oocytes and in ES cell lines derived from them
有丝分裂后神经元的染色体构成,通过神经元核转移到卵母细胞及其衍生的 ES 细胞系中进行评估
DOI:
10.1159/000230004
发表时间:
2009
期刊:
Cytogenet Genome Res
影响因子:
1.7
作者:
[T. Osada, N. Kakazu, M. Watanabe, H. Yamane, T. Yagi]
通讯作者:
T. Yagi
Clinicopathological Research Group for Localized Prostate Cancer Investigators. Discrepancy between local and central pathological review of radical prostatectomy specimens.
局部前列腺癌研究人员的临床病理学研究小组。
DOI:
--
发表时间:
2010
期刊:
J Urol
影响因子:
--
作者:
[K. Kuroiwa, T. Shiraishi, O. Ogawa, M. Usami, Y. Hirano, S. Naito]
通讯作者:
S. Naito
共 23 条
Functional analysis of magnetic nanoparticles and the related gene for prostate cancer therapy
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批准号:24592379
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2012
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负责人:WATANABE Masatoshi
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Pilot study on developmental of planning in ill-defined problem solvingby children with mild to moderate intellectual disabilities
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批准号:22730716
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资助金额:$1.33万
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财政年份:2010
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负责人:WATANABE Masatoshi
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依托单位:
Analysis of epigenetic mechanisms of nuclear receptor expression in prostatic carcinogenesis
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批准号:13670170
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:2001
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负责人:WATANABE Masatoshi
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依托单位:
Analysis of Vitamin A-related receptors expression in prostate cancer
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批准号:11671549
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:WATANABE Masatoshi
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依托单位:
海外基金