Manifestation of the HGF-related factor and influence of the invasion and proliferation in prostate cancer.

我们研究了肝细胞生长因子激活物（HGFA）抑制剂1型（HAI-1）在前列腺癌中的表现。HAI-1是HGFA的抑制剂。免疫组化结果显示，HAI-1在前列腺上皮细胞中表达，在间质细胞中未见表达。前列腺活检组织中HAI-1表达阴性。我们将HAI-1表达强度定义为阴性、弱、中等和强。我们分析了HAI-1表达与几个临床病理因素的关系。HAI-1在前列腺癌患者中的表达显著高于前列腺活检阴性者。HAI-1表达在临床分期或肿瘤分级方面无显著差异。然而，去势抵抗性前列腺癌显示出比未治疗的转移性前列腺癌显著更低的HAI-1表达。

We investigated manifestation in prostate cancer of hepatocyte growth factor activator(HGFA) inhibitor type 1(HAI-1). HAI-1 is inhibitor for HGFA. HAI-1 appeared in prostate epithelial cell, but did not appear in stromal cell by immunohistochemistry(IHC). Examination with prostate biopsy specimens, the HAI-1 expression was not observed for some case. We defined HAI-1 expression intensity as negative, weak, moderate and strong. We analyzed the relationship between HAI-1 expression and several clinicopathological factors. Expression of HAI-1 by IHC in patients with prostate cancer was significantly higher than those with negative for prostate biopsy. There were no significant differences in HAI-1 expression with respect to clinical stages or tumor grades. However castration resistance prostate cancer showed significantly lower HAI-1 expression than untreated metastatic prostate cancer.