Mechanism of tumor regulation by galactose-binding protein in hormone refractory prostate cancer

半乳糖结合蛋白在激素难治性前列腺癌中的肿瘤调控机制

• 批准号: 21592048
• 负责人: FUKUMORI Tomoharu
• 金额: $ 2.91万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592048/
• 关键词: 前立腺癌; ガレクチンー3; ホルモン不応性; ホルモン受容体; 遺伝子治療; ガレクチン-3

Galectin-3, has been strongly expressed in hormone-refractory prostate cancer, showed a negative correlation between expression of androgen receptor and galectin-3 in hormone-refractory prostate cancer cell line PC3. Galectin-3 was involved in resistance to apoptosis induced by platinum-based drug and radio therapy through the suppression of the caspase-3 activity and stability of the mitochondria. Galectin-3 is a target protein involved in the resistance of hormone therapy, chemotherapy and radiotherapy in hormone-refractory prostate cancer.

Galectin-3在激素非依赖性前列腺癌中高表达，在激素非依赖性前列腺癌PC3细胞中，雄激素受体的表达与Galectin-3的表达呈负相关。Galectin-3通过抑制caspase-3的活性和线粒体的稳定性参与铂类药物和放射治疗诱导的细胞凋亡抵抗。Galectin-3是一种靶蛋白，参与激素非依赖性前列腺癌激素治疗、化疗和放射治疗的耐药。

项目成果

Clinical significance of Galectin-3 in clear cell renal cell carcinoma

• DOI: 10.2152/jmi.57.152
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF MEDICAL INVESTIGATION
• 影响因子: 0.7
• 作者: Sakaki, Manabu;Fukumori, Tomoharu;Kanayama, Hiro-Omi
• 通讯作者: Kanayama, Hiro-Omi

前立腺癌I-125密封小線源療法におけるネオアジュバンド内分泌療法の有用性

新辅助内分泌治疗在前列腺癌 I-125 近距离放射治疗中的应用

• 发表时间: 2009
• 作者: 湯浅健;羽渕友則;湯浅健;Shiirevnyamba A;Takahiro Koizumi;Sakaki M;Nakanishi R;アビルメド・シーレンヤンバ;中逵弘能;松村英理;中逵弘能;松村英理;S Avirmed;中逵弘能;中逵弘能;福森知治;福森知治
• 通讯作者: 福森知治

The Role of Actinin-4 in Bladder Cancer Invasion

• DOI: 10.1016/j.urology.2009.09.037
• 发表时间: 2010-02-01
• 期刊: UROLOGY
• 影响因子: 2.1
• 作者: Koizumi, Takahiro;Nakatsuji, Hiroyoshi;Kanayama, Hiroomi
• 通讯作者: Kanayama, Hiroomi

Participation of N-caderin in bladder cancer

N-caderin参与膀胱癌的发生

• 发表时间: 2011
• 作者: 久末伸一;井手久満;吉井 隆;知名俊幸;磯谷周治;斉藤恵介;小関達郎;常盤紫野;永栄美香;山口雷蔵;武藤 智;堀江重郎;S Avirmed,Uehara H,Nakatsiji H,Fukawa T,Takemura M,Yamamoto Y,Yamaguchi K Kishimot T,Izaki H,Takahashi M,Fukumori T,Kanayama H;久末伸一;S Avilmed;Shin-ichi Hisasue;アビルメド・シーレンヤンバ
• 通讯作者: アビルメド・シーレンヤンバ

The Involvement of Actinin-4 in Bladder cancer Metastasi

Actinin-4 参与膀胱癌转移

• 发表时间: 2009
• 作者: 村林奈緒、杉山隆;他5名;中逵弘能
• 通讯作者: 中逵弘能