A study on changes of microcirculation of the bladder wall caused by bladder outlet obstruction and effects of alpha adrenoceptor antagonists on impaired bladder microcirculation

膀胱出口梗阻引起的膀胱壁微循环变化及α肾上腺素受体拮抗剂对膀胱微循环障碍的影响研究

• 批准号: 21592070
• 负责人: GOTOH Momokazu
• 金额: $ 2.08万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592070/
• 关键词: 下部尿路閉塞; 膀胱機能障害; 膀胱微小循環; 膀胱血流; 交感神経α1遮断薬; 膀胱虚血再灌流; 膀胱過伸展; 前立腺肥大症; 交感神経α遮断薬; 膀胱虚血再潅流; 膀胱虚血再灌流障害; 膀胱虚血

A bladder over-distension model, an ischemia-reperfusion model and a bladder outlet obstruction(BOO) model were created in rats, and microcirculation of the bladder wall was evaluated in those model rats using a pencil lens charge-coupled device microscopy system. In addition, the effect of sympathetic alpha-1 adrenoceptor(AR) antagonists on bladder microcirculation was assessed. From the results of the present study, it is suggested that bladder dysfunction occurs by an impairment of blood flow and ischemia-reperfusion injury in bladder outlet obstruction due to benign prostatic hyperplasia. Sympathetic alpha-1A AR antagonist will improve the bladder function by protecting the impairment of blood flow and ischemia-reperfusion injury.

建立大鼠膀胱过度扩张模型、缺血再灌注模型和膀胱出口梗阻（BOO）模型，采用铅笔形透镜电荷耦合器件显微镜系统观察膀胱壁微循环。此外，评估了交感神经α-1肾上腺素受体（AR）拮抗剂对膀胱微循环的影响。从本研究的结果，这是建议，膀胱功能障碍发生的血流障碍和缺血再灌注损伤膀胱出口梗阻由于良性前列腺增生。交感神经α-1A受体拮抗剂可通过保护血流障碍和缺血再灌注损伤来改善膀胱功能。

项目成果

Effect of tamsulosin on baldder microcirculation in a rat ischemia-reperfusion model, evaluated by pencil lens charge-coupled device microscopy system.

通过铅笔透镜电荷耦合器件显微镜系统评估坦索罗辛对大鼠缺血再灌注模型中秃头微循环的影响。

• 发表时间: 2010
• 作者: Mizuno H;Yamamoto T;Aota Y;Gotoh M.
• 通讯作者: Gotoh M.

Effect of tamsulosin on bladder microcirculation in a rat ischemia-reperfusion model

坦索罗辛对大鼠缺血再灌注模型膀胱微循环的影响

• 发表时间: 2010
• 期刊: evaluated by pencil lens charge-coupled device microscopy system Uology 76(5)
• 作者: Mizuno Y;Yamamoto T;Okutsu H;Ohtake A;Samata;Matsukawa Y;Funahashi Y;Kato M;Hattori R;Gotoh M
• 通讯作者: Gotoh M

下部尿路閉塞モデルラットにおける塩酸タムスロシンの膀胱微小循環に対する作用の可視化

盐酸坦索罗辛对下尿路梗阻模型大鼠膀胱微循环影响的可视化

• 发表时间: 2010
• 作者: 水野秀紀;山本徳則;松川宜久;服部良平;後藤百万
• 通讯作者: 後藤百万

Visualization of the effect of tamsulosin hydrochloride on bladder microcirculation in a rat bladder outlet obstruction model, evaluated by pencil lens charge-coupled device microscopy system.

通过铅笔透镜电荷耦合器件显微镜系统评估盐酸坦索罗辛对大鼠膀胱出口梗阻模型中膀胱微循环的影响的可视化。

• 发表时间: 2010
• 作者: Mizuno H;Yamamoto T;Aota Y;Gotoh M.
• 通讯作者: Gotoh M.

下部尿路閉塞と膀胱血流障害:α1ブロッカーによる症状改善メカニズムを探る

下尿路梗阻与膀胱血流障碍：探索α1阻滞剂改善症状的机制

• 发表时间: 2010
• 作者: Mochizuki T;Sokabe T;Araki I;Fujishita K;Shibasaki K;Uchida K;Koizumi S;Takeda M;Tominaga M;後藤百万
• 通讯作者: 後藤百万