A study on changes of microcirculation of the bladder wall caused by bladder outlet obstruction and effects of alpha adrenoceptor antagonists on impaired bladder microcirculation

建立大鼠膀胱过胀模型、缺血再灌注模型和膀胱出口梗阻（BOO）模型，利用铅笔透镜电荷耦合器件显微镜系统对模型大鼠膀胱壁微循环进行评价。此外，我们还评估了交感α -1肾上腺素受体拮抗剂对膀胱微循环的影响。从本研究结果来看，膀胱功能障碍的发生可能是由于良性前列腺增生引起的膀胱出口梗阻引起血流障碍和缺血再灌注损伤。交感α - 1a AR拮抗剂可通过保护血流障碍和缺血再灌注损伤来改善膀胱功能。

A bladder over-distension model, an ischemia-reperfusion model and a bladder outlet obstruction(BOO) model were created in rats, and microcirculation of the bladder wall was evaluated in those model rats using a pencil lens charge-coupled device microscopy system. In addition, the effect of sympathetic alpha-1 adrenoceptor(AR) antagonists on bladder microcirculation was assessed. From the results of the present study, it is suggested that bladder dysfunction occurs by an impairment of blood flow and ischemia-reperfusion injury in bladder outlet obstruction due to benign prostatic hyperplasia. Sympathetic alpha-1A AR antagonist will improve the bladder function by protecting the impairment of blood flow and ischemia-reperfusion injury.