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Research of prevention for urolithiasis considering gene and environmental factor, related metabolic syndrome.

Research of prevention for urolithiasis considering gene and environmental factor, related metabolic syndrome.
考虑基因和环境因素、相关代谢综合征的尿石症预防研究。
批准号：
21592076
负责人：
FUJITA Keiji
金额：
$2.91万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592076/
关键词：
尿路結石症メタボリックシンドロームアディポサイトカインストレス感受性シグナルオステオポンチン結石モデルマウスOPNノックアウトマウスOPNトランスジェニックマウス酸化ストレス

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中文摘要
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英文摘要
Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.
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会议论文
PROSTATE GROWTH INHIBITION BY SUBTYPE-SELECTIVE ALPHA1-ADRENOCEPTOR ANTAGONIST NAFTOPIDIL IN BENIGN PROSTATIC HYPERPLASIA
DOI： 10.1016/s0022-5347(09)61432-4
发表时间： 2009-04
期刊： The Journal of Urology
影响因子： --
作者： [Y. Kojima;S. Sasaki;N. Oda;M. Hayase;Y. Kubota;Y. Hayashi;M. Kiniwa;K. Kohri]
通讯作者： Y. Kojima;S. Sasaki;N. Oda;M. Hayase;Y. Kubota;Y. Hayashi;M. Kiniwa;K. Kohri
Effects of microgravity enhancement of oxidative stress in human renal tubular cells.
微重力增强人肾小管细胞氧化应激的影响。
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [Itoh Yasunori, Yasui Takahiro, Okada Atsushi, Hirose Masahito, Hamamoto Shuzo, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro]
通讯作者： Kohri Kenjiro
Genome-Wide Analysis of Genes Related to Kidney Stone Formation and Elimination in the Calcium Oxalate Nephrolithiasis Model Mouse: Detection of Stone-Preventive Factors and Involvement of Macrophage Activity
DOI： 10.1359/jbmr.081245
发表时间： 2009-05-01
期刊： JOURNAL OF BONE AND MINERAL RESEARCH
影响因子： 6.2
作者： [Okada, Atsushi, Yasui, Takahiro, Kohri, Kenjiro]
通讯作者： Kohri, Kenjiro
Genome-wide association study identifies new susceptibility loci for urolithiasis.
全基因组关联研究确定了尿石症的新易感位点。
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [Usami Masayuki, Itoh Yasunori, Tozawa Keiichi, Matsuda Koichi, Nakamura Yusuke, Kohri Kenjiro]
通讯作者： Kohri Kenjiro
共 36 条
    A new treatment agent determining renal calcium crystallization through cyclophilin D activation.
    • 批准号：
      24592434
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.41万
    • 财政年份：
      2012
    • 负责人：
      FUJITA Keiji
    • 依托单位：
      Nagoya City University
    Developing a taxonomy of university instructional processes and improving teaching strategies based on the analysis of video-logged classes
    A Theoretical and Experimental Study of the Transformational Process of Iconic and Verbal Information in Audiovisual Instructional Materials
    • 批准号：
      03401015
    • 项目类别：
      Grant-in-Aid for General Scientific Research (A)
    • 资助金额：
      $6.72万
    • 财政年份：
      1991
    • 负责人：
      FUJITA Keiji
    • 依托单位：
      National Institute of Multimedia Education
    Analyses of Broadcasting Educational TV Programs and Audience Behaviors
    • 批准号：
      62410017
    • 项目类别：
      Grant-in-Aid for General Scientific Research (A)
    • 资助金额：
      $7.04万
    • 财政年份：
      1987
    • 负责人：
      FUJITA Keiji
    • 依托单位：
      National Institute of Multimedia Education
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