To investigate of anti-neoplastic effect of metformin in endometrial cancer

1)观察了二甲双胍在体外和体内对子宫内膜癌细胞株和子宫内膜癌患者的抗肿瘤活性。二甲双胍在预防和治疗子宫内膜癌方面似乎是一种有效的治疗方法。2)本研究的复发率低于先前的研究。二甲双胍可能抑制甲孕酮治疗后子宫内膜癌的复发。二甲双胍还改善了年轻子宫内膜癌患者的胰岛素抵抗，这些患者有患糖尿病的风险。

1) The anti-neoplastic activity of metformin was observed in vitro and in vivo in endometrial cancer cell lines and in patients with endometrial cancer. Metformin appears to be a useful therapy in the prevention and treatment of patients with endometrial cancer.2) The recurrence rate in our study was lower than that observed in the previous study. Metformin may inhibit endometrial cancer recurrence after MPA therapy. Metformin also improved insulin resistance in young endometrial cancer patients who were at risk of developing diabetes mellitus.