Understanding the functional disorders of the auditory organ and development of effective treatment methods

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A finite-element model of the active cochlea was constructed with considering the outer hear cell(OHC) motility, and the effects of the OHC on hearing ability were investigated. In addition, by modeling the ion channels of the inner hear cells(IHCs), the OHCs and the cells which compose the stria vascularis and the spiral ligament of cochlear duct, the time-domain response of the membrane potential of the hair cells and endocochlear potential(EP) was simulated with changing the vibration amplitude and frequency applied to the stereocilia. The EP decreased when the function of each channel was impaired, and the functional loss of the hair cells was caused by the change of the EP.