Protection against respiratory infection during neonate to infant periods by maternal intranasal immunization

肺炎球菌疫苗在预防肺炎球菌感染方面起着重要作用。然而，婴儿表现出受损的先天性和适应性免疫应答，这导致抗肺炎球菌抗体的诱导不足。目前的研究表明，肺炎球菌表面蛋白A免疫的母鼠产生的后代中抗肺炎球菌特异性抗体的高度诱导。这一结果为肺炎球菌疫苗的研制提供了新的策略。

Pneumococcal vaccine plays an important role in protection against pneumococcal infections. However, infants exhibit impaired innate and adaptive immune responses, which result in insufficient induction of anti-pneumococcal antibody. The current study demonstrated the highly induction of anti-pneumococcal specific antibody among offspring delivered from mother mice immunized with pneumococcal surface protein A. This result would conduce a novel strategy of the development of pneumococcal vaccine.