Research of the mechanism of lymph node metastasis in nasopharyngeal carcinoma with bio-assay model

血管内皮生长因子-C/血管内皮生长因子受体-3轴参与了淋巴管生成的诱导，导致鼻咽癌的淋巴扩散。然而，Epstein-Barr病毒相关的潜伏膜蛋白-1与舌癌的发病机制无关，了解舌癌区域淋巴结中淋巴管生成的状态有助于预测哪些患者会发生淋巴结复发。因此，阻断淋巴管生成因子的治疗方法可能有利于抑制结内淋巴管生成强烈的舌癌的淋巴扩散。

The involvement of vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 axis in the induction of lymphangiogenesis results in lymphatic spread of nasopharyngeal carcinoma. However, Epstein-Barr virus-associated latent membrane protein-1 was not associated with the mechanism.Knowing the status of lymphangiogenesis in the regional lymph nodes in tongue cancer would help in predicting which patients will develop nodal recurrence. Thus, therapeutic approach which blocks lymphangiogenic factors may be beneficial in suppressing the lymphatic spread of tongue cancer with intense intranodal lymphangiogenesis.