Function of the human macula flava and voval fold stellate cells in the human vocal fold

人声带黄斑和卵瓣星状细胞的功能

• 批准号: 21592209
• 负责人: SATO Kiminori
• 金额: $ 2.58万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592209/
• 关键词: ヒト声帯; 黄斑; 声帯星型細胞; 細胞外マトリックス; ヒト声帯星細胞; メカノトランスダクション; ヒト声帯星型細胞; Mechanotransductio; Mechanotransduction

The result of the present study support our hypothesis that the tension caused by phonation(vocal fold vibration) after birth stimulate the vocal fold stellate cells in the anterior and posterior maculae flavae to accelerate production of extracellular matrices and form the vocal ligament, Reinke's space, and characteristic layered structure of the human vocal fold mucosa. This suggests that the vocal fold vibration(phonation) after birth and mechanotransduction of the vocal fold stellate cells in the maculae flavae are important factors in the growth and development of the human vocal fold mucosa.The vocal fold stellate cells in the human maculae flavae are desmin-positive cells with perinuclear vitamin A droplets and show the morphological features of the cells included in the proposed diffuse stellate cell system. The vocal fold stellate cells are considered to be a new category of cells in the human vocal fold. The maculae flavae are believed to be special microenvironments or niches, that nurture a pool of vocal fold stellate cells

本研究结果支持了我们的假设，即出生后发声引起的张力（声带振动）刺激黄斑前后的声带星状细胞，加速细胞外基质的产生，形成人声襞粘膜的韧带、赖因克间隙和特有的层状结构。提示出生后的声带振动（发声）和黄斑内声带星状细胞的机械转导是人声带粘膜生长发育的重要因素。人黄斑声带星状细胞是核周含有维生素A微滴的聚散蛋白阳性细胞，具有弥漫性星状细胞系统的细胞形态特征。声带星状细胞被认为是人类声带中一类新的细胞。黄斑被认为是一种特殊的微环境或生态位，它培育了一群声带星状细胞

项目成果

Histopathologic study of human vocal fold mucosa unphonated over a decade

十年来不发声的人类声带粘膜的组织病理学研究

• DOI: 10.3109/00016489.2011.615067
• 发表时间: 2011
• 期刊: Acta Oto-laryngologica
• 影响因子: 1.4
• 作者: Sato K;et al
• 通讯作者: et al

発声経験がないヒト小児声帯粘膜の組織構造

从未经历过发声的人类儿童声带粘膜的组织学结构

• 发表时间: 2009
• 作者: 佐藤公則、梅野博仁、中島格;野中聡、原渕保明
• 通讯作者: 野中聡、原渕保明

Stellate Cells in the Human Child Vocal Fold Macula Flava

人类儿童声带黄斑中的星状细胞

• 发表时间: 2009
• 期刊: Laryngoscope 119
• 作者: Sato Kiminori;Nakashima Tadashi
• 通讯作者: Nakashima Tadashi

Histopathologic Investigations of the Unphonated Human Child Vocal Fold Mucosa

• DOI: 10.1016/j.jvoice.2010.10.006
• 发表时间: 2012-01-01
• 期刊: JOURNAL OF VOICE
• 影响因子: 2.2
• 作者: Sato, Kiminori;Umeno, Hirohito;Harabuchi, Yasuaki
• 通讯作者: Harabuchi, Yasuaki

Functional Histology of the Macula Flava in the Human Vocal Fold Its Roles in the Growth and Development of the Vocal Fold

人类声带黄斑的功能组织学及其在声带生长发育中的作用

• 发表时间: 2010
• 期刊: Folia Phoniatr Logop
• 作者: SATO Kiminori;UMENO Hirohito;NAKASHIMA Tadashi
• 通讯作者: NAKASHIMA Tadashi