Roles of macrophages in the development of allergic conjunctival diseases

巨噬细胞在过敏性结膜疾病发展中的作用

• 批准号: 21592259
• 负责人: FUKUSHIMA Atsuki
• 金额: $ 2.41万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592259/
• 关键词: アレルギー; 結膜; 抗原提示細胞; FcεRIα; 好塩基球; T細胞; マクロファージ; 好酸球; 免疫染色; 電子顕微鏡

Vernal keratoconjunctivitis(VKC) is a severe form of allergic conjunctival diseases and may lead to blindness. VKC is an antigen-specific disease and antigen-presenting cels play crucial roles in its development. During this research period, we found that basophils are exerting antigen-presenting capability in allergic conjunctival diseases.

春季角结膜炎（VKC）是一种严重的过敏性结膜疾病，可导致失明。VKC是一种抗原特异性疾病，抗原提呈系统在其发生发展中起着至关重要的作用。在本研究期间，我们发现嗜碱性粒细胞在过敏性结膜疾病中发挥抗原提呈能力。

项目成果

Participation of CD11b and F4/80 Molecules in the Conjunctival Eosinophilia of Experimental Allergic Conjunctivitis

• DOI: 10.1159/000236002
• 发表时间: 2010-01-01
• 期刊: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
• 影响因子: 2.8
• 作者: Fukushima, Atsuki;Ishida, Waka;Yagita, Hideo
• 通讯作者: Yagita, Hideo

Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis

在实验性过敏性结膜炎的发展过程中，结膜巨噬细胞充当结膜中的抗原呈递细胞

• 发表时间: 2010
• 期刊: Mol Vision
• 作者: Ishida W;Kajisako M;Takahashi A;Sumi T;van Rooijen N;Fukuda K;Fukushima A
• 通讯作者: Fukushima A

Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice

在诱导期或效应期使用 FTY720 治疗可抑制小鼠实验性过敏性结膜炎的发展

• 发表时间: 2009
• 期刊: Cell Biol Int 33
• 作者: Sumi T;Fukushima A;Nishino K;Fukuda K;Kumagai N;Nishida T;Ueno H.
• 通讯作者: Ueno H.

The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway

• DOI: 10.1128/mcb.01836-08
• 发表时间: 2009-07-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Sakamoto, Shuji;Aoki, Kazuma;Agata, Yasutoshi
• 通讯作者: Agata, Yasutoshi

Severe allergic keratoconjunctivitis

严重过敏性角结膜炎

• 发表时间: 2010
• 作者: Ozawa Y.;Atsuki Fukushima
• 通讯作者: Atsuki Fukushima