Synaptic Inputs Switching Functional Modes in Primary Sensory Neurons of Rat Trigeminal Mesencephalic Nucleus

由于中脑三叉神经核（MTN）中的初级感觉神经元（psn）在接受各种类型受体（如谷氨酸能i型AMPA受体通道（AMPARCh））的突触输入方面是独一无二的，因此MTN神经元被认为不仅作为psn，而且作为独立于外周受体活动的中间神经元（Saito et al., 2006）。在本研究中，我们已经证明，在大鼠MTN神经元中，由保持电位超极化、泄漏K^+电流激活或PKA激活引起的h电流增强抑制了amparch介导的电流，并可能使MTN神经元切换到PSN功能模式。

Since primary sensory neurons(PSNs) in the mesencephalic trigeminal nucleus(MTN) are unique in receiving synaptic inputs onto various types of receptors such as a glutamatergic type-I AMPA receptor channel(AMPARCh), MTN neurons are thought to act not only as PSNs but also but also as interneurons independent of the activities of the peripheral receptors(Saito et al., 2006). In this study, we have demonstrated that in the rat MTN neurons, enhancement of h-current, caused by hyperpolarization of holding potential, activation of leak K^+ current or PKA activation, suppresses AMPARCh-mediated currents and might switch the MTN neuron to the PSN function mode.