Developments of scaffolds and processing technology to maximize the osteogenic potential of cultured periosteal sheets

我们的目标是开发快速处理方法和新型支架的人骨膜片。一般来说，由合成的可生物降解聚合物制成的支架不适合细胞粘附。然而，我们的多孔PLLA支架能够很好地固定骨膜片。这种支架还可以促进细胞外基质和细胞渗透到深孔区域。在这个项目中，我们成功地开发了几种有前途的生物可降解高分子材料支架。

We aimed to develop the fast processing methodology and novel scaffolds for human periosteal sheets. In general, scaffolds made of synthetic biodegradable polymers are not suitable for cell adhesion. However, our porous PLLA scaffold was capable of well securing periosteal sheets. This scaffold also functioned to facilitate extracellular matrices and cell penetration into deep pore regions. In this project, we have successfully developed several promising scaffolds with biodegradable polymermaterials.