Mesenchymal stem cells-photocurable gelatin-based gelation material for application to periodontal regeneration

间充质干细胞-光固化明胶基凝胶材料在牙周再生中的应用

• 批准号: 21592501
• 负责人: NAKAGAWA Taneaki
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592501/
• 关键词: 再生歯学; 間葉系幹細胞; 歯周組織再生; 足場材料; 光硬化型ゼラチン; 細胞分化誘導; 組織再生; 足場; 幹細胞; 光硬化性ゼラチン; 動物実験

We confirmed that prospective isolatedMSCs showed a 120, 000-fold higher colony forming frequency thanthe conventional MSCs. Furthermore, Our results suggested that MSCs in adultbone marrow have at least two developmental origins, one of which is the neural crest. Furthermore, prospectively enrichedMSCs are a promising candidate for the efficient generation of high-quality iPS cells. This photocurable solution also has adequate viscosity at room temperature before curing, and it manipulation is enhanced. It is assumed that forms suitable for various bone defects will thus be easily rendered, and it is also assumed that the shape can be retained with the mechanical strength required by photocurable.

我们证实，前瞻性分离的MSC比常规MSC显示出120倍的菌落形成频率。此外，我们的结果表明，成人骨髓中的MSC至少具有两个发育起源，其中一个是神经rest。此外，前瞻性富集是有效产生高质量IPS细胞的有前途的候选人。在固化前，该光固定溶液在室温下还具有足够的粘度，并且它的操作得到了增强。假定适合各种骨缺损的形式将很容易呈现，并且还假定可以使用光能验证所需的机械强度来保留形状。

项目成果

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation

• DOI: 10.1016/j.expneurol.2010.04.020
• 发表时间: 2010-08-01
• 期刊: EXPERIMENTAL NEUROLOGY
• 影响因子: 5.3
• 作者: Mukaino, Masahiko;Nakamura, Masaya;Okano, Hideyuki
• 通讯作者: Okano, Hideyuki

Inhibition of Abcg2 transporter on primitive hematopoietic stem cells by All-trans retinoic acid increases sensitivity to anthracycline

• DOI: 10.2492/inflammregen.30.55
• 发表时间: 2010-01
• 期刊: Inflammation and Regeneration
• 影响因子: 8.1
• 作者: Lawrence Lein;Y. Nagai;Y. Mabuchi;Sadafumi Suzuki;S. Morikawa;Y. Matsuzaki

間葉系幹細胞の一部は神経堤から発生する

一些间充质干细胞起源于神经嵴

• 发表时间: 2009
• 作者: 森川暁;深谷千絵;穂坂康朗;中川種昭
• 通讯作者: 中川種昭

Isolation and Identification of Mesenchymal Stem Cells in Human Bone Marrow

人骨髓间充质干细胞的分离与鉴定

• 发表时间: 2009
• 作者: Mabuchi;Yo(発表者);Morikawa;Satoru;Suzuki;Sadafumi;Lein;Lawrence;Niibe;Kunimichi;Nagai;Yasuo;Sunabori;Takehiko;Okano;Hideyuki;Matsuzaki;Yumi;Yo Mabuchi;馬渕洋
• 通讯作者: 馬渕洋

Improvement of Hydrogelation Abilities and Handling of Photocurable Gelatin-based Crosslinking Materials

• DOI: 10.1002/jbm.b.31406
• 发表时间: 2009-10-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
• 影响因子: 3.4
• 作者: Fukaya, Chie;Nakayama, Yasuhide;Nakagawa, Taneaki
• 通讯作者: Nakagawa, Taneaki