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The search of graded epigenetic change of oral cancer and Neighboring epithelial dysplasia

The search of graded epigenetic change of oral cancer and Neighboring epithelial dysplasia
口腔癌及邻近上皮异型增生分级表观遗传改变的探索
批准号:
21592519
负责人:
FUJITA Hajime
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We obtained a tissue specimen of normal tissue(N), epithelial dysplasia(D) and cancer(C), and extracted genomic DNA from the sample of two carcinoma of mandibular gingiva. We analyzed DNA methylation using illumina HumanMethylation27 and conducted the statistical analysis of the results. The gene which a methylation level rose to progressively in N group→D group→C group was EPDR1, FOXL1, FLJ21159, HOXB4, PRAC, DAPK1, FLJ46156, WDR8, BARHL2, NFAM1. Conversely, the gene which a methylation level decreased progressively was MEGEA3, GJB7, MFAP2, GPLD1, LOC348645, MEGEA6, FCN2, CCL1, SLC24A2, C9orf84. For the cancellation of the individual difference, it will be necessary to increase cases in future.
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DOI: 10.1002/ijc.24297
发表时间: 2009-06-15
期刊: INTERNATIONAL JOURNAL OF CANCER
影响因子: 6.4
作者: [Hirano, Chizuru, Nagata, Masaki, Takagi, Ritsuo]
通讯作者: Takagi, Ritsuo
DOI: 10.1016/j.ijom.2009.05.001
发表时间: 2009-09
期刊: International journal of oral and maxillofacial surgery
影响因子: 2.4
作者: [H. Fujita;T. Kobayashi;H. Tai;M. Nagata;H. Hoshina;R. Nishizawa;R. Takagi;H. Yoshie]
通讯作者: H. Fujita;T. Kobayashi;H. Tai;M. Nagata;H. Hoshina;R. Nishizawa;R. Takagi;H. Yoshie
下顎骨エナメル上皮腫・腺様歯原性腫瘍ハイブリッド腫瘍の1例
下颌牙釉质上皮瘤与牙源性腺样体瘤混合瘤一例
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Yoshiyuki Mori, Takafumi Susami, Daichi Chikazu, Hideto Saijo, Miyuki Sakiyama, Masako Matsuzaki, Masako Abe, Mamiko Wada, Mitsuyoshi Iino, and Tsuyoshi Takato, 藤田一,池田順行,齋藤太郎,高木律男,林孝文,山崎学,朔敬]
通讯作者: 藤田一,池田順行,齋藤太郎,高木律男,林孝文,山崎学,朔敬
Localization of Riemann-Roch number via torus bundles and its application
Susceptible gene search using single nucleotide polymorphism analysis in multiple primary oral cancer
  • 批准号:
    19592286
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2007
  • 负责人:
    FUJITA Hajime
  • 依托单位:
Assessment of 14 candidate gene polymorphisms as a risk factor for oral lichen planus in Japanese population
  • 批准号:
    17592067
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.24万
  • 财政年份:
    2005
  • 负责人:
    FUJITA Hajime
  • 依托单位:
Study on the effect of the boundary layer on the generation of aerodynamic noise and its control method.
  • 批准号:
    09450084
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $8.64万
  • 财政年份:
    1997
  • 负责人:
    FUJITA Hajime
  • 依托单位:
海外基金