Effects of intravenous sedation on higher brain function and development of new intravenous sedatives

本文研究了急性应激对大鼠脑单胺类神经活动的影响。采用微透析方法研究了抗焦虑剂和镇静剂对中枢神经系统的作用。该方法表明，焦虑剂和镇静剂抑制应激状态下蓝斑-内侧前额叶皮层去甲肾上腺素神经活动的增强，腹侧被盖区-伏隔核多巴胺神经元活动的增强，以及rape -amygdala - 5 -羟色胺神经元活动的增强。

We studied effects of the acute stress on monoamine neural activity in the rat brain The actions of the anxiolytis and sedatives on the central nervous system have been studied by microdialysis. This approach has shown that anxiolytis and sedatives suppress the accentuation of the locus coeruleus-medial prefrontal cortex noradrenaline neural activity, the accentuation of the ventral tegmental area-nucleus accumbens dopamine neuron activity, and the accentuation of the raphe-amygdala serotonin neuron activity in the stress state.