Action Mechanism of Stress in the Higher Brain Mechanisms and Modulation of Sedation

应激认知和情绪表现是通过复杂的脑神经网络机制形成的高级脑功能。选择性抗焦虑药、选择性镇静剂和苯并氮平对这些高级脑功能的影响，用微透析法进行了检测。通过给药时脑内神经递质的运动情况，考察了实验动物在不麻醉、不约束和自由运动状态下的应激负荷时间。结果表明，选择性抗焦虑药、选择性镇静剂和苯甲氮平对蓝斑(LC) -前额叶皮层（PFC）去甲肾上腺素神经活性和腹侧被盖区(VTA) -伏隔核（N.Acc）多巴胺神经活性有不同的作用。在应激状态下，去甲肾上腺素和VTA- n.c。苯二氮卓类药物控制多巴胺神经活动。选择性抗焦虑药仅控制LC-PFC去甲肾上腺素神经活动。选择性镇静剂只控制VTA-N。Acc。多巴胺神经活动。选择性抗焦虑药和选择性镇静剂对大脑神经网络的不同作用参与了一种抗焦虑药和镇静药的选择，表现出不同于苯并氮平系统药物的肌肉松弛作用，起源于LC，未出现。选择性抗焦虑药和选择性镇静剂对上呼吸道阻塞和抑制呼吸的作用较小。认为其原因是没有起源于LC的肌肉松弛作用。

The stress cognition and the emotional appearance are the higher brain functions formed with complex brain neural network mechanisms. The influence of selective anxiolytics, selective sedatives, and benzogeazepins to these higher brain functions, were examined used with microdiaiysis. The load time of the stress, and these drugs, laboratory animal in no anesthetizing, unrestraint, and the state of the freely moving were examined from the movement of the neurotransmitters in the brain when administering them.As a result, it was shown that selective anxiolytics, selective sedatives, and benzogeazepins had different actions for the locus coeruleus (LC) - prefrontal cortex (PFC) norepinephrine nerve activity and ventral tegmental area (VTA) - nucleus accumbens (N.Acc.) dopamine nerve activity. Both of the norepinephrine nerve activity in the state of stress and VTA- N.Acc. dopamine nerve activity controlled by benzodiazepines. Selective anxiolytics controlled only the LC-PFC norepinephrine nerve activity. Selective sedatives controlled only the VTA-N. Acc. dopamine nerve activity. Differed the action on the neural network in the brain taking part in the selection of an anxyolytic action and sedative actionSelective anxiolytics and the selective sedatives showed the muscle relax action which differed from benzogeazepin system medicine, and originated in LC and it was shown not to appear. As for selective anxiolytics and selective sedatives have a few effect of the upper airway obstruction and depress breathing . It was thought that there was no muscle relax action which originated in LC as the reason.