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Action Mechanism of Stress in the Higher Brain Mechanisms and Modulation of Sedation

高级脑机制中的应激作用机制和镇静调节

基本信息

批准号：
12470446
负责人：
KAWAHARA Hiroshi
金额：
$ 7.1万
依托单位：
Kyushu Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470446/
关键词：
Stress Microdialysis Neuronal Network Monoamine Neurons Locus Ceruleus Prefrontal Cortex Benzodiazepine Anxiolytics

项目摘要

The stress cognition and the emotional appearance are the higher brain functions formed with complex brain neural network mechanisms. The influence of selective anxiolytics, selective sedatives, and benzogeazepins to these higher brain functions, were examined used with microdiaiysis. The load time of the stress, and these drugs, laboratory animal in no anesthetizing, unrestraint, and the state of the freely moving were examined from the movement of the neurotransmitters in the brain when administering them.As a result, it was shown that selective anxiolytics, selective sedatives, and benzogeazepins had different actions for the locus coeruleus (LC) - prefrontal cortex (PFC) norepinephrine nerve activity and ventral tegmental area (VTA) - nucleus accumbens (N.Acc.) dopamine nerve activity. Both of the norepinephrine nerve activity in the state of stress and VTA- N.Acc. dopamine nerve activity controlled by benzodiazepines. Selective anxiolytics controlled only the LC-PFC norepinephrine nerve activity. Selective sedatives controlled only the VTA-N. Acc. dopamine nerve activity. Differed the action on the neural network in the brain taking part in the selection of an anxyolytic action and sedative actionSelective anxiolytics and the selective sedatives showed the muscle relax action which differed from benzogeazepin system medicine, and originated in LC and it was shown not to appear. As for selective anxiolytics and selective sedatives have a few effect of the upper airway obstruction and depress breathing . It was thought that there was no muscle relax action which originated in LC as the reason.

应激认知和情绪表象是由复杂的脑神经网络机制形成的高级脑功能。选择性抗焦虑药、选择性镇静药和苯扎平类药物对这些高级脑功能的影响用显微透析法进行了检查。在给药时，从脑内神经递质的运动来检查应激和这些药物的负荷时间，实验动物在没有麻醉、不受约束和自由活动的状态下。和苯扎地平对蓝斑（LC）-前额叶皮层（PFC）-去甲肾上腺素神经活动和腹侧被盖区（VTA）的作用不同。黑核多巴胺神经活动应激状态下的去甲肾上腺素神经活动和腹侧被盖区- N.Acc.多巴胺神经活动均受苯二氮卓类药物控制。选择性抗焦虑药仅控制LC-PFC去甲肾上腺素神经活动。选择性镇静剂仅控制VTA-N。加速多巴胺神经活动。选择性抗焦虑药和选择性镇静药对脑神经网络的作用不同，表现出与苯并咪唑类药物不同的肌肉松弛作用，起源于LC，未出现。而选择性抗焦虑药和选择性镇静药对上呼吸道阻塞和呼吸抑制的影响较小。这被认为是没有肌肉松弛的行动，起源于LC的原因。