Effects of intravenous sedatives on higher brain function and basic research of development of new intravenous sedatives

静脉镇静剂对高级脑功能的影响及新型静脉镇静剂开发的基础研究

• 批准号: 17592096
• 负责人: KAWAHARA Hiroshi
• 金额: $ 2.24万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17592096/
• 关键词: Stress; Chaos; Pharmacology; Neuroscience; Plethysmogram; Lyapunov Exponent; Microdialysis; Dentistry

The development of non-benzodiazepine drugs that have only the anxiolytic or sedative action of benzodiazepines started in the latter half of the 1980's. These drugs have been developed using two approaches: development of partial benzodiazepine receptor agonists, and development of drugs with selectivity for the a subunit of the GABAA receptor, at which the benzodiazepine receptor binding site exists. Anxioselective drugs have been developed using the former approach, whereas sedative-selective drugs have emerged from the latter.The actions of the anxioselective drug Y-23684 and the sedative-selective drug zolpidem on the central nervous system have been studied by dual-probe microdialysis. This approach has shown that anxioselective drugs suppress accentuation of the locus coeruleus-medial prefrontal cortex norepinephrine neural activity under stress, while sedative-selective drugs suppress accentuation of the ventral tegmental area-nucleus accumbens dopamine neuron activity in the stress state. These findings suggest that the difference in the effect on the neural network relates to the selectivity for anxiolytic or sedative action.

仅具有苯二氮卓类药物的抗焦虑或镇静作用的非苯二氮卓类药物的开发始于20世纪80年代后半期。这些药物的开发采用两种方法：开发部分苯二氮卓受体激动剂，以及开发对苯二氮卓受体结合位点存在的GABAA受体a亚基具有选择性的药物。焦虑选择性药物是使用前一种方法开发的，而镇静选择性药物是由后一种方法产生的。采用双探针微透析法研究了焦虑选择性药物Y-23684和镇静选择性药物唑吡坦对中枢神经系统的作用。该方法表明，焦虑选择性药物抑制应激状态下蓝斑-内侧前额叶皮层去甲肾上腺素神经活动的增强，而镇静选择性药物抑制应激状态下腹侧被盖区-伏隔核多巴胺神经元活动的增强。这些发现表明，对神经网络影响的差异与抗焦虑或镇静作用的选择性有关。

项目成果

虚血性脊髄障害における神経保護 : 脊髄microdialysisによる検討

缺血性脊髓损伤的神经保护：脊髓微透析检查

• 发表时间: 2007
• 期刊: 日本歯科麻酔学会雑誌 35
• 作者: 佐藤靖臣;石川敏三;仲西修;河原博;椎葉俊司;門脇啓治
• 通讯作者: 門脇啓治

Differential effects of long-term administration of citalopram on the function of alpha 2-adrenoreceptors in the amygdale and locus coeruleus

长期服用西酞普兰对杏仁核和蓝斑α2-肾上腺素受体功能的不同影响

• 发表时间: 2006
• 期刊: Monitoring Moleculeus in Neuroscience 11
• 作者: Morimoto;Y.;Kawahara H.
• 通讯作者: Kawahara H.

歯科麻酔学入門

牙科麻醉学简介

• 发表时间: 2005
• 作者: Chibana Y;Kawamata H;at al.;河原 博
• 通讯作者: 河原 博

指尖脈波リアプノフ指数測定装置-リアルタイムカオス特性モニター-

指尖脉搏波李亚普诺夫指数测量装置-实时混沌特性监测-

• 发表时间: 2006
• 期刊: 日本歯科麻酔学会雑誌 34
• 作者: Harada K;Tamatani T;Bando T;Kawashima Y;Yoshida H;A Case of Oral Squamous Cell Carcinoma;河原 博
• 通讯作者: 河原 博

Differntial effects of long-term administration of citalopram on the function of alpha 2-adrenoreceptors in the amygdale and locus coeruleus

长期服用西酞普兰对杏仁核和蓝斑α2-肾上腺素受体功能的不同影响

• 发表时间: 2006
• 期刊: Monitoring Moleculeus in Neuroscience 11
• 作者: Kawamata H.;et al.;Kawahara H.
• 通讯作者: Kawahara H.