Analysis of the influence on the host cells of FDF derived from periodontopathic bacteria and the contribution in the pathogenesis of periodontitis

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The FDF was taken in(or invade) a cell and raised oxidation membrane potential after reaching to mitochondria, and it was revealed that the FDF finally aggravated production of IL-8. The gingival crevicular fluid from periodontitis patients and normal subjects(for each 21) was isolated, and measured the anti-FDF antibody titer each. As a result, the antibody titer of periodontitis patients showed significantly higher than that of control group. Furthermore, 3 clinical parameters(Pocket depth, Clinical Attachment Level(CAL) and Bleeding on probing) are correlated with the anti-FDF antibody titer. These results suggest that the titer was associated with the condition of patients.