Analysis of the influence on the host cells of FDF derived from periodontopathic bacteria and the contribution in the pathogenesis of periodontitis

牙周病菌FDF对宿主细胞的影响及其在牙周炎发病机制中的贡献分析

• 批准号: 21592620
• 负责人: ARAKAWA Shinichi
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592620/
• 关键词: 歯周免疫機能学; 歯周病原細菌; FDF; 歯周病; 抗FDF抗体; Tannerella forsythia; 歯周炎; 歯肉溝滲出液

The FDF was taken in(or invade) a cell and raised oxidation membrane potential after reaching to mitochondria, and it was revealed that the FDF finally aggravated production of IL-8. The gingival crevicular fluid from periodontitis patients and normal subjects(for each 21) was isolated, and measured the anti-FDF antibody titer each. As a result, the antibody titer of periodontitis patients showed significantly higher than that of control group. Furthermore, 3 clinical parameters(Pocket depth, Clinical Attachment Level(CAL) and Bleeding on probing) are correlated with the anti-FDF antibody titer. These results suggest that the titer was associated with the condition of patients.

FDF进入（或侵入）细胞，到达线粒体后，氧化膜电位升高，并显示FDF最终促进IL-8的产生。分离牙周炎患者和正常人（各21例）龈沟液，测定抗FDF抗体效价。结果表明，牙周炎患者血清抗体滴度明显高于对照组。此外，3个临床参数（囊袋深度、临床附着水平（CAL）和探测出血）与抗FDF抗体滴度相关。这些结果表明，滴度与患者的病情有关。

项目成果

オゾンナノバブル水-安全性・歯周補助治療としての有効性-

臭氧纳米气泡水-作为牙周辅助治疗的安全性和有效性-

• 发表时间: 2010
• 作者: 大西英知;荒川真一;中島琢磨;和泉雄一;Udagawa N;荒川真一,早雲彩絵,眞野喜洋,和泉雄一;中道裕子;早雲彩絵,荒川真一,眞野喜洋,和泉雄一;宇田川信之;荒川真一
• 通讯作者: 荒川真一

ストレスと歯周炎.,日本歯科医師会雑誌

压力与牙周炎，日本牙科协会杂志

• 发表时间: 2011
• 期刊: 国際歯科ニュース
• 作者: 和泉雄一;荒川真一
• 通讯作者: 荒川真一

Levels of specific immunoglobulin G to the forsythia detaching factor of Tannerella forsythia in gingival crevicular fluid are related to the periodontal status

龈沟液中针对连翘泰氏菌分离因子的特异性免疫球蛋白G水平与牙周状态相关

• 发表时间: 2010
• 期刊: J Periodntol Res
• 作者: Hidetomo Onishi;Shinichi Arakawa;Takumi Nakajima;Yuichi Izumi.
• 通讯作者: Yuichi Izumi.

歯周炎患者由来歯肉溝滲出液がTannerellaforsythia FDFに与える影響

牙周炎患者龈沟渗出液对福赛坦氏菌FDF的影响

• 发表时间: 2011
• 作者: 中道裕子;他;大西英知,荒川真一,中島琢磨,和泉雄一
• 通讯作者: 大西英知,荒川真一,中島琢磨,和泉雄一

Levels of specificimmunoglobulin G to the forsythia detachingfactor of Tannerella forsythia in gingivalcrevicular fluid are related to the periodontalstatus

龈沟液中针对连翘分离因子的特异性免疫球蛋白G水平与牙周状况相关

• 发表时间: 2010
• 期刊: J Periodontal Res
• 影响因子: 3.5
• 作者: Hidetomo Onishi;Shinichi Arakawa;Takumi Nakajima;Yuichi Izumi
• 通讯作者: Yuichi Izumi