Involvement of cytokine network in the pathology of neuropathic pain following peripheral nerve injury

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Tumor necrosis factor(TNF)-alpha is one of a pro-inflammatory cytokines that may play a key role for the induction of neuropathic pain following nerve injury. However, the precise histological expression of TNF alpha and its receptors mRNA in the spinal cord after nerve injury is not fully understood. TNF alpha mRNA showed the transient increase from 18 hour and peaked at 24 hour following SNI. In the spinal cord of naive rats, TNF alpha and TNFR2 showed a low level expression and TNFR1 mRNA signal was detected in neurons and glial cells in the dorsal horn. Twenty-four hours after SNI, TNF alpha mRNA signals increased in the ipsilateral microglia. TNFR1 and TNF R2 mRNA signals increased strikingly in ipsilateral glial cells at 3 days after SNI.