Monitoring of social behavior associated with onset of hearing loss used model mice

为了积累听力损失发生后社会行为的基础数据，我们使用DBA/2J（D2，早发性听力损失模型）和C57BL/6J（B6，迟发性听力损失模型）之间的F2小鼠进行旷场活动分析。 F2小鼠被分为听力正常组（NH）和听力损伤组（HI），我们发现HI小鼠与NH小鼠相比明显保持在同一位置。另外，HI小鼠的移动时间比NH小鼠慢；这些结果表明，HI 小鼠通过听力缺陷影响自主行为。通过QTL分析，我们鉴定了4号染色体上与移动时间显着相关的QTL。此外，基因型D2/D2纯合子的F2小鼠在4号染色体标记处的移动时间明显慢于BALB/B6杂合子和B6/B6纯合子小鼠。

To accumulate the basic data of social behavior after onset of hearing loss, we analyzed open field activities using by F2 mice between DBA/2J(D2, model for early-onset hearing loss) and C57BL/6J(B6, model for late-onset hearing loss). The F2 mice were classified as groups of normal hearing(NH) and hearing impairment(HI), and we detected that HI mice significantly remained in the same place compared with the NH mice. In addition, HI mice were slower than NH mice in the moving time ; these results suggested that HI mice affect voluntary behavior by hearing defects. By QTL analysis, we identified QTLs on chromosome 4 that significantly associated with the moving time. Moreover, F2 mice of genotype D2/D2 homozygote at a marker of chromosome 4 associated with the moving times that were significantly slower than BALB/B6 heterozygote and B6/B6 homozygote mice.