The diagnosis of the risk of periodontitis: searching for the interleukin-6 receptor

牙周炎风险的诊断：寻找白细胞介素6受体

• 批准号: 21792114
• 负责人: KOMATSU Yasutaka
• 金额: $ 2.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792114/
• 关键词: 歯周炎; IL-6; IL-6レセプター; IL-6受容体

Soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) are key molecules in regulation of IL-6 response. Multiple logistic regression analysis revealed significant association between genetic polymorphisms of IL-6R+48892 (A/C) and susceptibility to periodontitis. Moreover, cell surface expression of membrane-bound IL-6R in PBMC and lymphocyte was significantly higher in subjects who carry IL-6R+48892 A allele than that who did not carry. These results suggest that IL-6R gene polymorphisms could act as a risk factor for chronic periodontitis by regulating immunological cell surface expression of IL-6R and sIL-6R levels.

可溶性白细胞介素-6受体（sIL-6 R）和可溶性糖蛋白130（sgp 130）是调节IL-6应答的关键分子。多因素Logistic回归分析显示IL-6 R +48892（A/C）基因多态性与牙周炎易感性相关。携带IL-6 R +48892 A等位基因的受试者PBMC和淋巴细胞膜结合IL-6 R的细胞表面表达显著高于不携带者。提示IL-6 R基因多态性可能通过调节IL-6 R和sIL-6 R的免疫细胞表面表达而成为慢性牙周炎的危险因素。

项目成果

歯周炎および関節リウマチ患者におけるIL-6遺伝子プロモーター領域のメチル化解析

牙周炎和类风湿关节炎患者IL-6基因启动子区甲基化分析

• 发表时间: 2010
• 作者: Kobayashi T;Murasawa A;Komatsu Y;Yokoyama T;Yamamoto K;Ishida K;Abe A;Yamamoto K;Yoshie H;Tetsuo Kobayashi;石田光平;小島杏里;Okada M;Kojima A;Kobayashi T;Ishida K;小林哲夫;小林哲夫;小林哲夫;Tetsuo Kobayashi;Kohei Ishida;Moe Okada;Anri Kojima;石田光平;Kobayashi T;Okada M;Ishida K;石田光平;Ishida K;Kobayashi T;石田光平
• 通讯作者: 石田光平

Cytokine Gene Polymorphisms Associated With Rheumatoid Arthritis and Periodontitis in Japanese Adults

• DOI: 10.1902/jop.2009.080573
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF PERIODONTOLOGY
• 影响因子: 4.3
• 作者: Kobayashi, Tetsuo;Murasawa, Akira;Yoshie, Hiromasa
• 通讯作者: Yoshie, Hiromasa

Genetic influence of senlm interleukin-6 and its soluble receptor levels

Senlm IL-6 及其可溶性受体水平的遗传影响

• 发表时间: 2010
• 作者: Takahashi N;Honda T;Domon H;Nakajima T;Tabeta K;Yamazaki K.;小松康高
• 通讯作者: 小松康高

Antibody Responses to Periodontopathic Bacteria in Relation to Rheumatoid Arthritis in Japanese Adults

• DOI: 10.1902/jop.2011.110020
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF PERIODONTOLOGY
• 影响因子: 4.3
• 作者: Okada, Moe;Kobayashi, Tetsuo;Yoshie, Hiromasa
• 通讯作者: Yoshie, Hiromasa

DNA methylation status of the interleukin-6 gene promoter in periodontitis

牙周炎中白细胞介素6基因启动子DNA甲基化状态

• 发表时间: 2010
• 作者: Kobayashi T;Murasawa A;Komatsu Y;Yokoyama T;Yamamoto K;Ishida K;Abe A;Yamamoto K;Yoshie H;Tetsuo Kobayashi;石田光平;小島杏里;Okada M;Kojima A;Kobayashi T;Ishida K;小林哲夫;小林哲夫;小林哲夫;Tetsuo Kobayashi;Kohei Ishida;Moe Okada;Anri Kojima;石田光平;Kobayashi T;Okada M;Ishida K;石田光平;Ishida K
• 通讯作者: Ishida K