The diagnosis of the risk of periodontitis: searching for the interleukin-6 receptor

可溶性白介素6受体(sIL-6R)和可溶性gp130(Sgp130)是调节IL-6反应的关键分子。多因素Logistic回归分析显示，IL-6R 48892(A/C)基因多态性与牙周炎易感性显著相关。此外，携带IL-6R 48892 A等位基因的患者外周血和淋巴细胞膜结合IL-6R的表达显著高于未携带IL-6R等位基因的患者。提示IL-6R基因多态性可能通过调节免疫细胞表面IL-6R和sIL-6R水平而成为慢性牙周炎的危险因素。

Soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) are key molecules in regulation of IL-6 response. Multiple logistic regression analysis revealed significant association between genetic polymorphisms of IL-6R+48892 (A/C) and susceptibility to periodontitis. Moreover, cell surface expression of membrane-bound IL-6R in PBMC and lymphocyte was significantly higher in subjects who carry IL-6R+48892 A allele than that who did not carry. These results suggest that IL-6R gene polymorphisms could act as a risk factor for chronic periodontitis by regulating immunological cell surface expression of IL-6R and sIL-6R levels.