Effect of obesity prevention by exercise training on periodontal tissue

研究表明，肥胖与牙周炎呈正相关。通过运动训练抑制肥胖可能会对牙周组织产生临床益处。本研究旨在探讨运动训练对高脂饮食肥胖大鼠牙周组织的影响。将42只雄性Wistar大鼠(8周龄)分为三组：对照组(常规饲料喂养)和两个实验组(高脂饲料加和不加运动训练[跑步机：5天/周])。实验周期为4周或8周。8周时，未经运动训练的肥胖大鼠血清ROM值、牙周组织中8-OHdG含量及结缔组织中多形核白细胞密度均高于对照组。运动训练后8周，肥胖大鼠血清ROM值、牙周8-OHdG水平和中性粒细胞密度均低于未运动训练组。这些结果表明，运动预防肥胖可通过降低血清ROM值而有效地抑制大鼠牙龈氧化应激和牙周炎。

Studies indicate a positive correlation between obesity and periodontitis. The suppression of obesity by exercise training may offer the clinical benefits on periodontal tissue. The purpose of the present study was to investigate the effects of exercise training on periodontal tissue in obese rats fed a high-fat diet. Forty-two male Wistar rats (8 week olds) were divided into three groups : a control group (fed a regular diet) and two experimental groups (fed a high-fat diet with and without exercise training [treadmill : 5 days/ week]). The experiment period was 4 or 8 weeks. The obese rats without exercise training showed higher serum ROM levels, 8-OHdG levels in gingival tissues, and polymorphonuclear leucocytes density in the connective tissues than the control group at 8 weeks. The obese rats with exercise training showed lower serum ROM levels, gingival 8-OHdG levels, and polymorphonuclear leucocytes density than those without exercise training at 8 weeks. These results indicate that obesity prevention by exercise training could effectively suppress gingival oxidative stress and periodontal inflammation by decreasing serum ROM in rats.