Effect of obesity prevention by exercise training on periodontal tissue

运动训练预防肥胖对牙周组织的影响

• 批准号: 21792150
• 负责人: AZUMA Tetsuji
• 金额: $ 2.41万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792150/
• 关键词: 肥満; 運動; 歯周組織; 酸化ストレス; ラット; 歯周病

Studies indicate a positive correlation between obesity and periodontitis. The suppression of obesity by exercise training may offer the clinical benefits on periodontal tissue. The purpose of the present study was to investigate the effects of exercise training on periodontal tissue in obese rats fed a high-fat diet. Forty-two male Wistar rats (8 week olds) were divided into three groups : a control group (fed a regular diet) and two experimental groups (fed a high-fat diet with and without exercise training [treadmill : 5 days/ week]). The experiment period was 4 or 8 weeks. The obese rats without exercise training showed higher serum ROM levels, 8-OHdG levels in gingival tissues, and polymorphonuclear leucocytes density in the connective tissues than the control group at 8 weeks. The obese rats with exercise training showed lower serum ROM levels, gingival 8-OHdG levels, and polymorphonuclear leucocytes density than those without exercise training at 8 weeks. These results indicate that obesity prevention by exercise training could effectively suppress gingival oxidative stress and periodontal inflammation by decreasing serum ROM in rats.

研究表明肥胖与牙周炎呈正相关。运动训练对肥胖的抑制可能对牙周组织有临床益处。本研究的目的是研究运动训练对喂食高脂肪饮食的肥胖大鼠牙周组织的影响。将42只雄性Wistar大鼠（8周龄）分为3组：对照组（喂食常规饮食）和2个实验组（喂食高脂饮食，加不加运动训练[跑步机：5天/周]）。试验期分别为4周和8周。8周时，未进行运动训练的肥胖大鼠血清ROM水平、牙龈组织8- ohdg水平和结缔组织多形核白细胞密度均高于对照组。8周时，运动训练的肥胖大鼠血清ROM水平、牙龈8- ohdg水平和多形核白细胞密度均低于未运动训练的肥胖大鼠。提示运动训练预防肥胖可通过降低大鼠血清ROM，有效抑制牙龈氧化应激和牙周炎症。

项目成果

Effects of periodontitis on aortic insulin resistance in an obese rat model

• DOI: 10.1038/labinvest.2009.141
• 发表时间: 2010-03-01
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Ekuni, Daisuke;Tomofuji, Takaaki;Morita, Manabu
• 通讯作者: Morita, Manabu

運動による肥満の予防が歯肉の酸化ストレスに及ぼす影響

运动预防肥胖对牙龈氧化应激的影响

• 发表时间: 2010
• 作者: 江國大輔;東哲司;入江浩一郎;遠藤康正;加藤朋;玉木直文;友藤孝明;森田学
• 通讯作者: 森田学

運動による肥満予防がラット歯周組織に及ぼす影響

运动预防肥胖对大鼠牙周组织的影响

• 发表时间: 2010
• 作者: 東哲司;入江浩一郎;遠藤康正;粕山健太;加藤 朋;江國大輔;玉木直文;友藤孝明;森田学
• 通讯作者: 森田学

Effects of exercise training on gingival oxidative stress in obese rats

• DOI: 10.1016/j.archoralbio.2011.01.008
• 发表时间: 2011-08-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Azuma, Tetsuji;Tomofuji, Takaaki;Morita, Manabu
• 通讯作者: Morita, Manabu

Experimental Periodontitis Induces Gene Expression of Proinflammatory Cytokines in Liver and White Adipose Tissues in Obesity

• DOI: 10.1902/jop.2009.090574
• 发表时间: 2010-04-01
• 期刊: JOURNAL OF PERIODONTOLOGY
• 影响因子: 4.3
• 作者: Endo, Yasumasa;Tomofuji, Takaaki;Morita, Manabu
• 通讯作者: Morita, Manabu