Non-standard peptide-probe discovery

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This research project aims at developing the genetic code reprogramming technology based on the flexizyme system and expressing natural product-like macrocyclic peptides from mRNA libraries. Moreover, an in vitro display system, referred to RaPID (Random nonstandard Peptide Integrated Discovery) system, has been established to apply for massive screenings of macrocyclic peptides generated by the above technology. This has enabled us to discover molecular probes against various drug targets, leading to a new era of chemical biology.