Chemistry of Novel Naturally Occurring Super-carbon-chain Molecules
Chemistry of Novel Naturally Occurring Super-carbon-chain Molecules
批准号:
21221009
负责人:
UEMURA Daisuke
金额:
$94.6万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
我们将海洋生物衍生的无重复基序的长碳链分子称为超碳链分子。它们具有特殊的化学结构和很强的生物活性。在这项研究中,我们试图通过一种新的方法来鉴定新的超碳链分子:大规模共生细菌培养或元基因组方法。我们还研究了这些分子的生物学意义、生物活性、生物合成和独特的化学反应活性。因此,我们成功地鉴定了几个重要的分子,并测定了它们的生物活性。我们的发现应该有助于建立超碳链分子的概念。
英文摘要
We refer to marine organism-derived long carbon chain molecules without repeating motifs as super-carbon-chain molecules. They have extraordinary chemical structures and exhibit strong biological activities. In this study, we endeavored to identify novel super-carbon-chain molecules by a new approach: the large-scale cultivation of symbiotic bacteria or a meta-genomic method. We also studied the biological significance, biological activities, biosynthesis, and unique chemical reactivities of these molecules. As a result, we successfully identified several important molecules and determined their biological activities. Our findings should help to establish the concept of super-carbon-chain molecules.
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DOI:
10.1016/j.chembiol.2010.10.017
发表时间:
2011-01-28
期刊:
CHEMISTRY & BIOLOGY
影响因子:
--
作者:
[Sato, Shin-ichi, Murata, Asako, Uesugi, Motonari]
通讯作者:
Uesugi, Motonari
Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotectivemediator, into intact cGMP in cells
一氧化氮促进 8-硝基-cGMP(一种细胞保护介质)再循环为细胞内完整的 cGMP
DOI:
10.1039/c2mb25189b
发表时间:
2012
期刊:
Moi BioSyst
影响因子:
--
作者:
[Yohei Saito, Tomohiro Sawa, Jun Yoshitake, Chiaki Ito, Shigemoto Fujii, Takaaki Akaike and Hirokazu Arimoto]
通讯作者:
Takaaki Akaike and Hirokazu Arimoto
Stereocontrolled synthesisi and structural confirmation of the C14-C24 degraded fragment of symbiodinolide
symbiodinolide C14-C24 降解片段的立体控制合成及结构确认
DOI:
--
发表时间:
2010
期刊:
Tetrahedron
影响因子:
2.1
作者:
[H.Takamura, Y.Kadonaga, I.Kadota, D.Uemura]
通讯作者:
D.Uemura
クロイソカイメンとハリコンドリンB
黑色海绵和软海绵素 B
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Ogasawara, H., H.Kato, G.Hofmann, D. Roberts, P.Piper, T. Clements, A.K.Ward, Y. Yabe, H. Yilmaz, R.J. Durrheim, R.J., 上村大輔]
通讯作者:
上村大輔
Lyngbyacyclamide Aの合成研究
Lyngbyacyclamide A的合成研究
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[増田駿, 鈴木祐太郎, 丸範人, 上村大輔]
通讯作者:
上村大輔
共 155 条
Pursuit of Substances in Dynamic Ecological Systems
-
批准号:16GS0206
-
项目类别:Grant-in-Aid for Creative Scientific Research
-
资助金额:$341.54万
-
财政年份:2004
-
负责人:UEMURA Daisuke
-
依托单位:
Anesthetic Substances and Other Key Compounds Related to Biologically Intriguing Phenomena
-
批准号:12045235
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$18.56万
-
财政年份:2000
-
负责人:UEMURA Daisuke
-
依托单位:
STUDIES ON SEARCH FOR ANTI-FOULING SUBSTANCES AND THEIR DEVELIPMENTS
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批准号:11558079
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.81万
-
财政年份:1999
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负责人:UEMURA Daisuke
-
依托单位:
Targeted Pursuit of Challenging Bioactive Molecules
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批准号:11175101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$189.5万
-
财政年份:1999
-
负责人:UEMURA Daisuke
-
依托单位:
Studies on Intensive Search of New Bioactive Marine Molecules and Their Supply for the Practical Uses
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批准号:08558068
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$3.71万
-
财政年份:1996
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负责人:UEMURA Daisuke
-
依托单位:
Chemical Studies on Super Carbon Cbain Compounds Produced by Dinoflagellates.
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批准号:02640423
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1990
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负责人:UEMURA Daisuke
-
依托单位: