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Chemistry of Novel Naturally Occurring Super-carbon-chain Molecules

Chemistry of Novel Naturally Occurring Super-carbon-chain Molecules
新型天然存在的超碳链分子的化学
批准号:
21221009
负责人:
UEMURA Daisuke
金额:
$94.6万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012

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项目成果

UEMURA Daisuke的其他基金

相关文献

中文摘要
翻译
我们将海洋生物衍生的无重复基序的长碳链分子称为超碳链分子。它们具有特殊的化学结构和很强的生物活性。在这项研究中,我们试图通过一种新的方法来鉴定新的超碳链分子:大规模共生细菌培养或元基因组方法。我们还研究了这些分子的生物学意义、生物活性、生物合成和独特的化学反应活性。因此,我们成功地鉴定了几个重要的分子,并测定了它们的生物活性。我们的发现应该有助于建立超碳链分子的概念。
英文摘要
We refer to marine organism-derived long carbon chain molecules without repeating motifs as super-carbon-chain molecules. They have extraordinary chemical structures and exhibit strong biological activities. In this study, we endeavored to identify novel super-carbon-chain molecules by a new approach: the large-scale cultivation of symbiotic bacteria or a meta-genomic method. We also studied the biological significance, biological activities, biosynthesis, and unique chemical reactivities of these molecules. As a result, we successfully identified several important molecules and determined their biological activities. Our findings should help to establish the concept of super-carbon-chain molecules.
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会议论文
DOI: 10.1016/j.chembiol.2010.10.017
发表时间: 2011-01-28
期刊: CHEMISTRY & BIOLOGY
影响因子: --
作者: [Sato, Shin-ichi, Murata, Asako, Uesugi, Motonari]
通讯作者: Uesugi, Motonari
Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotectivemediator, into intact cGMP in cells
一氧化氮促进 8-硝基-cGMP(一种细胞保护介质)再循环为细胞内完整的 cGMP
DOI: 10.1039/c2mb25189b
发表时间: 2012
期刊: Moi BioSyst
影响因子: --
作者: [Yohei Saito, Tomohiro Sawa, Jun Yoshitake, Chiaki Ito, Shigemoto Fujii, Takaaki Akaike and Hirokazu Arimoto]
通讯作者: Takaaki Akaike and Hirokazu Arimoto
Stereocontrolled synthesisi and structural confirmation of the C14-C24 degraded fragment of symbiodinolide
symbiodinolide C14-C24 降解片段的立体控制合成及结构确认
DOI: --
发表时间: 2010
期刊: Tetrahedron
影响因子: 2.1
作者: [H.Takamura, Y.Kadonaga, I.Kadota, D.Uemura]
通讯作者: D.Uemura
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Ogasawara, H., H.Kato, G.Hofmann, D. Roberts, P.Piper, T. Clements, A.K.Ward, Y. Yabe, H. Yilmaz, R.J. Durrheim, R.J., 上村大輔]
通讯作者: 上村大輔
155
    Pursuit of Substances in Dynamic Ecological Systems
    Anesthetic Substances and Other Key Compounds Related to Biologically Intriguing Phenomena
    • 批准号:
      12045235
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $18.56万
    • 财政年份:
      2000
    • 负责人:
      UEMURA Daisuke
    • 依托单位:
    STUDIES ON SEARCH FOR ANTI-FOULING SUBSTANCES AND THEIR DEVELIPMENTS
    • 批准号:
      11558079
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.81万
    • 财政年份:
      1999
    • 负责人:
      UEMURA Daisuke
    • 依托单位:
    Targeted Pursuit of Challenging Bioactive Molecules
    • 批准号:
      11175101
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $189.5万
    • 财政年份:
      1999
    • 负责人:
      UEMURA Daisuke
    • 依托单位: