Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

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Integrated research project for nucleic acids drug has been directed to nano-medicines that can target pathogenetic geneses. Achievements on chemical research for the artificial functional oligonucleotides, determination of the target genes, delivery system for selective targeting cells or tissues, and validation of the nano-medicine using model animals have been accumulates by mutual collaboration.Newly-developed reactive oligonulceotides (ODN) are encapsulated in beta-MEND to target beta-cells, which are delivered into MIN6 cells of beta cell line, resulting in increase of insulin by releasing its native inhibition by miRNA-375 system. Bonkrekic acid, an apoptosis inhibitor, enhanced its activity by encapsulation in MITO-Porter, a mitochondria- targeting delivery system. siRNA targeting Drp1 gene was encapsulated in YSK-MEND (liver-targeting nano-envelope) for validate its effect for the model animal, and a potential as a new therapeutic approach has been suggested.