Research and development of hypoxia-detecting luminescent probe iridium complex and its application to endoscopic imaging probes

发光探针的缺点是其激发/发射光的组织穿透性低。为了克服这一限制，我们创建了一种新的 BTO 衍生物 BTPHSA，它可以在近红外区域发出 710 nm 的发射光。该探针使肿瘤可见，这些肿瘤被移植到小鼠皮肤表面 1.5 厘米深的腹膜内。为了进一步提高 BTP 类似物的组织累积能力，我们创建了添加二甲基部分的 BTP，BTO-DM，它使小鼠体内的肿瘤通过常规剂量的十分之一的 BTP 可见。我们相信这些创新的 BTP 衍生物将在内窥镜成像领域开辟新的应用。

The drawback of luminescent probes is low tissue penetration of its excitation/emission light. To overcome this limitation, we created a new BTO derivative BTPHSA, which gives 710 nm emission light in the near infrared region. This probe enables tumors visible, which are transplanted 1.5 cm deep intraperitoneally from the skin surface in mice. To further increase tissue-accumulating capability of BTP analogues, we created dimethyl moiety-added BTP, BTO-DM, which enables tumors visible by a tenth of regular dosage of BTP in mice. We believe these innovative BTP derivatives will open up their new application to endoscopic imaging.