Understanding and control of biodegradability of bioabsorbable Mg alloys

镁合金的降解性能取决于合金的种类，这与植入部位周围软组织中形成的气穴量有关。即使对于具有快速降解速率的镁合金，也没有观察到异常的炎症。由于伴随降解的OH-释放而导致的局部pH升高可能在超过细胞可接受的范围时抑制细胞生长。用生物可吸收医用聚合物涂覆纯镁可有效降低纯镁的初始降解速率，并成功地改善细胞相容性。

Degradation properties of Mg alloys depend on the kind of alloys, which relates to the amount of gas cavity formed in the soft tissue surrounding the implant site. Extraordinary inflammation was not observed even for the Mg alloy having rapid degradation rate. The local pH increase due to the OH- release accompanying the degradation may suppress cell growth when it goes over the acceptable range of cells. Coating of pure Mg with bioabsorbable medical polymers is effective to reduce initial degradation rate of pure Mg and successfully improves cytocompatibility.